SRF and CAMK2A

Number of citations of the paper that reports this interaction (PubMedID 8413226)
78

Data Source:
HPRD (in vitro, in vivo)

		SRF	CAMK2A
Description		serum response factor	calcium/calmodulin dependent protein kinase II alpha
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Dendrite Endocytic Vesicle Membrane Cell Projection Neuron Projection Dendritic Spine Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Leukocyte Differentiation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Actin Filament Organization Cell-matrix Adhesion Gastrulation Heart Development Long-term Memory Negative Regulation Of Cell Population Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Actin Cytoskeleton Organization Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Thyroid Gland Development Forebrain Development Neuron Projection Development Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis Wound Healing Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Filopodium Assembly Thymus Development Developmental Growth Neuron Development Axon Extension Erythrocyte Development Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Long-term Synaptic Depression Face Development Heart Trabecula Formation Cardiac Muscle Cell Myoblast Differentiation Lung Morphogenesis Bronchus Cartilage Development Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Lung Smooth Muscle Development Establishment Of Skin Barrier Bicellular Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Cell-cell Adhesion Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Interferon-beta Angiotensin-activated Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Calcium Ion Transport Long-term Synaptic Potentiation Dendritic Spine Development Cellular Response To Type II Interferon Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Peptidyl-threonine Autophosphorylation Regulation Of Endocannabinoid Signaling Pathway Regulation Of Neuron Migration
Pathways		RHO GTPases Activate Formins NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling Cardiogenesis Regulation of NPAS4 gene transcription	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime} Fostamatinib
Diseases
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Retinitis pigmentosa ( 33514863) Ulcerative colitis ( 28067908)
Interacting Genes		71 interacting genes: ALDH3A1 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 FOXG1 FOXK1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MRTFA MRTFB MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARA REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 TRIP4 UBE2I ZIC3	89 interacting genes: ACTN1 ACTN2 ACTN4 ARID5A ATF1 ATP2A2 C1orf94 CACNA1B CAMK2N2 CDC37 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DAZAP2 DLG1 DSCAM EGFR ETS1 FAM168A FAM168B FXR1 GFAP GLB1L2 GRIA1 GRIN1 GRIN2A GRIN2B GRM5 HSF1 HYAL3 ITGA2B ITGB1BP1 ITPKA KRT18 KRT75 KRT76 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP22-1 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LENG8 LRRC7 MAPT MPDZ MRPL11 NOS1 NTAQ1 PDC PPM1F PSMC5 PTTG1 RALYL RBFOX2 RBM47 RBPMS RBPMS2 RCHY1 RHOXF2 RIMS1 SMAD2 SOX5 SPMIP9 SQSTM1 SRF STAT1 SUOX SYNGAP1 TAB2 TANC1 TCAF1 TFAP2D TIAL1 TRIM55 TRIM63 TSR2 TTC5 VARS1 YWHAB ZBTB32
Entrez ID		6722	815
HPRD ID		02788	06532
Ensembl ID		ENSG00000112658	ENSG00000070808
Uniprot IDs		B4DU24 P11831	A0A5F9ZH21 A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs		1HBX 1K6O 1SRS	2VZ6 3SOA 5IG3 6OF8 6VZK 6W4O 6W4P 6X5G 6X5Q 7KL0 7KL1 7KL2 7REC 7UIQ 7UIR 7UIS 7UJP 7UJQ 7UJR 7UJS 7UJT 9EOY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Transcription Cis-regulatory Region Binding DNA Binding Animal Organ Development Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Differentiation Negative Regulation Of RNA Metabolic Process Cellular Developmental Process Developmental Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Response To Lipid Muscle Cell Differentiation DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process	Intermediate Filament Regulation Of Synaptic Plasticity Dendritic Spine Modulation Of Chemical Synaptic Transmission Learning Or Memory Cognition Postsynaptic Density Glutamate-gated Calcium Ion Channel Activity Identical Protein Binding Neuron Projection Glutamate Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Excitatory Postsynaptic Potential Associative Learning Positive Regulation Of Synaptic Transmission Synapse Postsynaptic Density Membrane Intracellular Signaling Cassette Learning Ligand-gated Ion Channel Signaling Pathway Regulation Of Membrane Potential Cytosol NMDA Glutamate Receptor Activity Cell Junction Organization Modulation Of Excitatory Postsynaptic Potential Transmembrane Transporter Binding Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Selective Glutamate Receptor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Postsynaptic Actin Cytoskeleton Excitatory Chemical Synaptic Transmission Kinase Binding Visual Behavior Positive Regulation Of Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Nucleobase-containing Compound Metabolic Process Synaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Protein Kinase Binding Regulation Of Nucleobase-containing Compound Metabolic Process Superior Olivary Nucleus Maturation
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