SRF and MYOCD

Number of citations of the paper that reports this interaction (PubMedID 12397177)
31

Data Source:
HPRD (in vitro, in vivo)

		SRF	MYOCD
Description		serum response factor	myocardin
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Activity Protein Binding Histone Acetyltransferase Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Leukocyte Differentiation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Actin Filament Organization Cell-matrix Adhesion Gastrulation Heart Development Long-term Memory Negative Regulation Of Cell Population Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Actin Cytoskeleton Organization Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Thyroid Gland Development Forebrain Development Neuron Projection Development Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis Wound Healing Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Filopodium Assembly Thymus Development Developmental Growth Neuron Development Axon Extension Erythrocyte Development Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Long-term Synaptic Depression Face Development Heart Trabecula Formation Cardiac Muscle Cell Myoblast Differentiation Lung Morphogenesis Bronchus Cartilage Development Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Lung Smooth Muscle Development Establishment Of Skin Barrier Bicellular Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Cell-cell Adhesion Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth By Extracellular Stimulus Vasculogenesis Response To Hypoxia Cardiac Ventricle Development Chromatin Organization Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiocyte Differentiation Vascular Associated Smooth Muscle Cell Differentiation Cellular Component Maintenance Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Lung Alveolus Development Digestive Tract Development Smooth Muscle Cell Differentiation Regulation Of Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Uterus Development Urinary Bladder Development Negative Regulation Of Cell Adhesion Molecule Production Cardiac Muscle Cell Myoblast Differentiation Cardiac Vascular Smooth Muscle Cell Differentiation Ductus Arteriosus Closure Negative Regulation Of Amyloid-beta Clearance Regulation Of Phenotypic Switching Positive Regulation Of MiRNA Transcription Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways		RHO GTPases Activate Formins NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling Cardiogenesis Regulation of NPAS4 gene transcription	Cardiogenesis
Drugs
Diseases
GWAS			Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) PR interval ( 30046033 30679814 32439900) QRS duration ( 31251759) Systolic blood pressure change trajectory ( 27980656) Testosterone levels ( 22675492)
Interacting Genes		71 interacting genes: ALDH3A1 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 FOXG1 FOXK1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MRTFA MRTFB MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARA REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 TRIP4 UBE2I ZIC3	11 interacting genes: GOPC GSK3B KDM3A MAMSTR MRTFA MYOD1 SMAD2 SMAD3 SMARCA4 SRF STUB1
Entrez ID		6722	93649
HPRD ID		02788	09362
Ensembl ID		ENSG00000112658	ENSG00000141052
Uniprot IDs		B4DU24 P11831	Q8IZQ8
PDB IDs		1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Transcription Cis-regulatory Region Binding DNA Binding Animal Organ Development Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Differentiation Negative Regulation Of RNA Metabolic Process Cellular Developmental Process Developmental Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Response To Lipid Muscle Cell Differentiation DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process	Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of MiRNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding Chromatin Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation R-SMAD Binding Negative Regulation Of MiRNA Transcription Ubiquitin Protein Ligase Binding Paraxial Mesoderm Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Regulation Of Developmental Process Regulation Of Muscle Cell Differentiation Tau Protein Binding Mesoderm Formation Regulation Of RNA Metabolic Process Gastrulation Mesoderm Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Pericardium Development Regulation Of Primary Metabolic Process Formation Of Primary Germ Layer SMAD Protein Complex Trophoblast Cell Migration Regulation Of Nucleobase-containing Compound Metabolic Process Heteromeric SMAD Protein Complex Nucleoplasm Transcription Regulator Complex Embryonic Foregut Morphogenesis Regulation Of Macromolecule Metabolic Process Nodal Signaling Pathway Co-SMAD Binding Positive Thymic T Cell Selection
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?