SRF and MYOD1

Number of citations of the paper that reports this interaction (PubMedID 8617811)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SRF	MYOD1
Description		serum response factor	myogenic differentiation 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Myofibril
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Serum Response Element Binding Chromatin DNA Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Primary MiRNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Enzyme Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Neuron Migration Trophectodermal Cell Differentiation Heart Looping Morphogenesis Of An Epithelial Sheet Cell Migration Involved In Sprouting Angiogenesis Leukocyte Differentiation Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Actin Filament Organization Cell-matrix Adhesion Gastrulation Heart Development Long-term Memory Negative Regulation Of Cell Population Proliferation Associative Learning Response To Toxic Substance Response To Hormone Epithelial Structure Maintenance Hippocampus Development Tangential Migration From The Subventricular Zone To The Olfactory Bulb Actin Cytoskeleton Organization Contractile Actin Filament Bundle Assembly Regulation Of Cell Adhesion Platelet Activation Platelet Formation Negative Regulation Of Cell Migration Thyroid Gland Development Forebrain Development Neuron Projection Development Response To Cytokine Megakaryocyte Development Dorsal Aorta Morphogenesis Wound Healing Stress Fiber Assembly Skin Morphogenesis Positive Thymic T Cell Selection Sarcomere Organization Positive Regulation Of Cell Differentiation Positive Regulation Of Axon Extension Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Transcription By Glucose Muscle Cell Cellular Homeostasis Filopodium Assembly Thymus Development Developmental Growth Neuron Development Axon Extension Erythrocyte Development Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Filopodium Assembly Cardiac Myofibril Assembly Angiogenesis Involved In Wound Healing Hematopoietic Stem Cell Differentiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Long-term Synaptic Depression Face Development Heart Trabecula Formation Cardiac Muscle Cell Myoblast Differentiation Lung Morphogenesis Bronchus Cartilage Development Trachea Cartilage Development Cardiac Vascular Smooth Muscle Cell Differentiation Eyelid Development In Camera-type Eye Lung Smooth Muscle Development Establishment Of Skin Barrier Bicellular Tight Junction Assembly Cellular Response To Glucose Stimulus Primitive Streak Formation Epithelial Cell-cell Adhesion Cellular Senescence Cell-cell Adhesion Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Phosphorylation Muscle Organ Development Myoblast Fate Determination Skeletal Muscle Tissue Development Myoblast Fusion Cellular Response To Starvation Tissue Development Regulation Of Gene Expression Myotube Differentiation Myotube Cell Development Myotube Differentiation Involved In Skeletal Muscle Regeneration Cell Differentiation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment Skeletal Muscle Tissue Regeneration Positive Regulation Of Skeletal Muscle Tissue Regeneration Regulation Of RNA Splicing Skeletal Muscle Fiber Adaptation Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Striated Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Positive Regulation Of Myoblast Fusion Positive Regulation Of SnRNA Transcription By RNA Polymerase II Negative Regulation Of Myoblast Proliferation
Pathways		RHO GTPases Activate Formins NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling Cardiogenesis Regulation of NPAS4 gene transcription	Myogenesis Myogenesis TGFBR3 expression
Drugs
Diseases
GWAS			Body mass index ( 26426971) Hodgkin's lymphoma ( 34216518) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		71 interacting genes: ALDH3A1 ATF6 BARX2 CAMK2A CASP3 CASP6 CASP7 CASP8 CASP9 CD63 CEBPB CIRBP CREB1 CREBBP CRIP2 CSNK2A1 ELK1 ELK4 ETV4 FHL1 FHL2 FHL3 FHL5 FLI1 FOXG1 FOXK1 GATA4 GTF2F1 GTF2I HDAC4 HMGA1 HOPX KAT5 KDM6A MAPKAPK2 MINPP1 MRTFA MRTFB MYOCD MYOD1 MYOG NCOA1 NCOA6 NCOR2 NFKB1 NFYA NKX2-3 NKX2-5 NKX3-1 OGT PML PRKDC PRRX1 PYCARD RARA REL RELA RPS6KA1 RXRA RXRG SHBG SP1 SRC SRFBP1 SSRP1 TCF3 TEAD1 TRIM63 TRIP4 UBE2I ZIC3	67 interacting genes: AKAP19 AP1M1 ASCL3 BHLHA15 BHLHE40 BHLHE41 CALM1 CALM2 CALM3 CARM1 CDC34 CDK2 CDK4 CDKN1C CIB2 CREBBP CSRP3 ELSPBP1 EP300 EXOC3L1 FBXO32 FIGLA HAND1 HDAC1 HEY1 HSP90AA1 ID1 ID2 ID3 ID4 IFRD1 IGFN1 JUN KAT2B KAT5 KPNA3 LMO4 MDFI MEF2A MEF2C MOS MYOCD NCOR1 NCOR2 NR2F2 PHB2 POLR2G PRKCA PRMT5 PSMD4 PSME2 RB1 RORA RUNX1 RXRA SETD3 SMAD3 SMAD4 SMAD7 SP1 SRF STAT3 SUV39H1 TCF21 TCF3 TCF4 TWIST1
Entrez ID		6722	4654
HPRD ID		02788	01166
Ensembl ID		ENSG00000112658	ENSG00000129152
Uniprot IDs		B4DU24 P11831	P15172
PDB IDs		1HBX 1K6O 1SRS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Transcription Cis-regulatory Region Binding DNA Binding Animal Organ Development Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cell Differentiation Negative Regulation Of RNA Metabolic Process Cellular Developmental Process Developmental Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Response To Lipid Muscle Cell Differentiation DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of RNA Metabolic Process Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein Dimerization Activity Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Nucleus Negative Regulation Of Macromolecule Metabolic Process BHLH Transcription Factor Binding Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Rhythmic Process Positive Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process Nucleoplasm Histone Deacetylase Binding Regulation Of Developmental Process E-box Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Differentiation Cell Differentiation Regulation Of Metabolic Process Circadian Rhythm Positive Regulation Of Cell Differentiation Cellular Developmental Process Transcription Cis-regulatory Region Binding Negative Regulation Of Developmental Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?