RANBP9 and ENTPD1

Number of citations of the paper that reports this interaction (PubMedID 16478441)
35

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		RANBP9	ENTPD1
Description		RAN binding protein 9	ectonucleoside triphosphate diphosphohydrolase 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Membrane Nuclear Body	Basement Membrane Plasma Membrane Caveola External Side Of Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Apyrase Activity GDP Phosphatase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nucleoside Diphosphate Phosphatase Activity Ribonucleoside Triphosphate Phosphatase Activity CDP Phosphatase Activity ADP Phosphatase Activity CTPase Activity UDP Phosphatase Activity ITPase Activity IDP Phosphatase Activity
	Biological Process	Cytoskeleton Organization Microtubule Nucleation Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process	Cell Adhesion G Protein-coupled Receptor Signaling Pathway Blood Coagulation Nucleoside Diphosphate Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Platelet Activation ADP Catabolic Process Platelet Aggregation
Pathways		L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling Regulation of pyruvate metabolism	Phosphate bond hydrolysis by NTPDase proteins Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Premature ovarian failure
GWAS		Breast cancer ( 23535729 29059683)	Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		67 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 BTG3 CACNA1G CALB1 CBR1 CBR3 CBS CCND1 CDK11B CDKN1A CFAP298 CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 GATD3 GID8 GRIK1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LCOR LMNA MAPK6 MET MORC3 MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOD1 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 ZBED1	1 interacting genes: RANBP9
Entrez ID		10048	953
HPRD ID		04835	09047
Ensembl ID		ENSG00000010017	ENSG00000138185
Uniprot IDs		Q96S59	P49961
PDB IDs		5JI7 5JI9 5JIU 7NSC
Enriched GO Terms of Interacting Partners?		Developmental Process Cellular Developmental Process Animal Organ Development Regulation Of Programmed Cell Death Nucleoplasm Protein-containing Complex Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Nuclear Receptor Activity Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Condensate Scaffold Activity Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Chromatin Binding Regulation Of Growth Apoptotic Signaling Pathway	Microtubule Nucleation Microtubule Associated Complex Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of ERK1 And ERK2 Cascade
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