RANBP9 and GRIK1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RANBP9	GRIK1
Description		RAN binding protein 9	glutamate ionotropic receptor kainate type subunit 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Membrane Nuclear Body	Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Synapse Postsynaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Protein Binding Enzyme Binding Small GTPase Binding	Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Cytoskeleton Organization Microtubule Nucleation Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Central Nervous System Development Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential
Pathways		L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling Regulation of pyruvate metabolism	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs			Glutamic acid Butabarbital Topiramate Tezampanel
Diseases
GWAS		Breast cancer ( 23535729 29059683)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Forehead morphology ( 29921221) Generalized epilepsy ( 30531953) Glucocorticoid-induced osteonecrosis ( 26265699) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Lung cancer ( 34062886) Periodontitis (DPAL) ( 24024966) Plasma parathyroid hormone levels ( 30134803) Refractive error ( 32231278) Response to statin therapy ( 20339536) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		67 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 BTG3 CACNA1G CALB1 CBR1 CBR3 CBS CCND1 CDK11B CDKN1A CFAP298 CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 GATD3 GID8 GRIK1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LCOR LMNA MAPK6 MET MORC3 MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOD1 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 ZBED1	31 interacting genes: COPS5 CYSLTR2 DLG4 DLST DNAJB9 FLNA GORASP2 GRIK2 GRIK3 GRIK4 GRIK5 GRIP1 HOMER1 HSP90B1 KALRN KCNQ2 LDB2 PICK1 PTPRD RANBP9 RNF123 SDCBP SEPTIN7 SIPA1L3 SNAPIN SRI ST13 TAAR1 UBE2O ZFC3H1 ZNF592
Entrez ID		10048	2897
HPRD ID		04835	00693
Ensembl ID		ENSG00000010017	ENSG00000171189
Uniprot IDs		Q96S59	B7Z256 B7Z3V7 E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086
PDB IDs		5JI7 5JI9 5JIU 7NSC	2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
Enriched GO Terms of Interacting Partners?		Developmental Process Cellular Developmental Process Animal Organ Development Regulation Of Programmed Cell Death Nucleoplasm Protein-containing Complex Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Nuclear Receptor Activity Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Condensate Scaffold Activity Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Chromatin Binding Regulation Of Growth Apoptotic Signaling Pathway	Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Regulation Of Cell Communication Regulation Of Signaling Synapse Cell-cell Signaling Signaling Cell Communication Modulation Of Chemical Synaptic Transmission Presynaptic Membrane Regulation Of Presynaptic Membrane Potential Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Hippocampal Mossy Fiber To CA3 Synapse Receptor Clustering Postsynaptic Membrane Localization Within Membrane Postsynaptic Density Monoatomic Ion Channel Activity Regulation Of Membrane Potential Dendrite Cytoplasm Protein Localization To Membrane Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Synaptic Transmission Glutamatergic Synapse Protein Sequestering Activity Plasma Membrane Synaptic Vesicle Maturation Neuron Spine Positive Regulation Of Neuron Projection Arborization Synaptic Vesicle Negative Regulation Of Synaptic Transmission, Glutamatergic Glutamate-gated Calcium Ion Channel Activity Regulation Of Signal Transduction Perikaryon Glutamate Receptor Activity Protein-containing Complex Localization Cellular Localization Regulation Of Neuron Projection Arborization Regulation Of Synaptic Transmission, Glutamatergic
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