RANBP9 and AXL

Number of citations of the paper that reports this interaction (PubMedID 15964779)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid, pull down)
HPRD (two hybrid)

		RANBP9	AXL
Description		RAN binding protein 9	AXL receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Membrane Nuclear Body	Extracellular Space Plasma Membrane Cell Surface Actin Cytoskeleton Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding Enzyme Binding Small GTPase Binding	Nucleotide Binding Virus Receptor Activity Phosphatidylserine Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Cytoskeleton Organization Microtubule Nucleation Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process	Neuron Migration Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine-mediated Signaling Pathway Blood Vessel Remodeling Immune System Process Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Spermatogenesis Nervous System Development Positive Regulation Of Signal Transduction Negative Regulation Of Macrophage Cytokine Production Cell Migration Forebrain Cell Migration Cell Differentiation Platelet Activation Negative Regulation Of Type II Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Secretion By Cell Erythrocyte Homeostasis Substrate Adhesion-dependent Cell Spreading Cellular Response To Interferon-alpha Ovulation Cycle Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Lymphocyte Activation Symbiont Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Positive Regulation Of Pinocytosis Regulation Of Lymphocyte Activation Negative Regulation Of Lymphocyte Activation Neuron Apoptotic Process Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vagina Development Cellular Response To Lipopolysaccharide Dendritic Cell Differentiation Neutrophil Clearance Mononuclear Cell Differentiation Positive Regulation Of Viral Life Cycle Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling Regulation of pyruvate metabolism	VEGFA-VEGFR2 Pathway
Drugs			Fostamatinib Gilteritinib
Diseases
GWAS		Breast cancer ( 23535729 29059683)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol ( 31170924) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Triglyceride levels ( 32154731 32203549)
Interacting Genes		67 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 BTG3 CACNA1G CALB1 CBR1 CBR3 CBS CCND1 CDK11B CDKN1A CFAP298 CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 GATD3 GID8 GRIK1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LCOR LMNA MAPK6 MET MORC3 MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOD1 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 ZBED1	24 interacting genes: ADAM10 CBL EGFR FBXO25 GAS6 GRB2 IL15RA IL2RG LCK MTDH NCK2 PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 RANBP9 SHC1 SHC3 SOCS1 SRC TNS2 TYRO3 UBC
Entrez ID		10048	558
HPRD ID		04835	00171
Ensembl ID		ENSG00000010017	ENSG00000167601
Uniprot IDs		Q96S59	M0R0W6 P30530
PDB IDs		5JI7 5JI9 5JIU 7NSC	2C5D 4RA0 5U6B 5VXZ
Enriched GO Terms of Interacting Partners?		Developmental Process Cellular Developmental Process Animal Organ Development Regulation Of Programmed Cell Death Nucleoplasm Protein-containing Complex Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Nuclear Receptor Activity Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Condensate Scaffold Activity Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Chromatin Binding Regulation Of Growth Apoptotic Signaling Pathway	Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Receptor Tyrosine Kinase Binding Leukocyte Activation Cell Activation Neurotrophin TRKA Receptor Binding Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Leukocyte Differentiation Positive Regulation Of Cell Activation Immune System Process Positive Regulation Of Immune System Process Signal Transduction Regulation Of Cell Activation Lymphocyte Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Immune System Process Lymphocyte Differentiation Regulation Of Cell Adhesion Regulation Of Intracellular Signal Transduction Positive Regulation Of T Cell Activation 1-phosphatidylinositol-3-kinase Regulator Activity Positive Regulation Of Multicellular Organismal Process Ephrin Receptor Binding Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Multicellular Organismal Process Protein Kinase Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction T Cell Activation Cell Migration Regulation Of Programmed Cell Death Protein Phosphatase Binding Response To Growth Factor Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA
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