RANBP9 and HMBS

Number of citations of the paper that reports this interaction (PubMedID 12917623)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		RANBP9	HMBS
Description		RAN binding protein 9	hydroxymethylbilane synthase
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Membrane Nuclear Body	Cytoplasm Cytosol
	Molecular Function	Protein Binding Enzyme Binding Small GTPase Binding	Hydroxymethylbilane Synthase Activity Protein Binding Transferase Activity
	Biological Process	Cytoskeleton Organization Microtubule Nucleation Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process	Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Tetrapyrrole Biosynthetic Process Heme O Biosynthetic Process
Pathways		L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling Regulation of pyruvate metabolism	Heme biosynthesis
Drugs
Diseases			Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS		Breast cancer ( 23535729 29059683)	Apolipoprotein A1 levels ( 32203549)
Interacting Genes		67 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 BTG3 CACNA1G CALB1 CBR1 CBR3 CBS CCND1 CDK11B CDKN1A CFAP298 CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 GATD3 GID8 GRIK1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LCOR LMNA MAPK6 MET MORC3 MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOD1 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 ZBED1	5 interacting genes: APP GSK3A PICK1 RANBP9 ZDHHC17
Entrez ID		10048	3145
HPRD ID		04835	01440
Ensembl ID		ENSG00000010017	ENSG00000256269
Uniprot IDs		Q96S59	A0A3F2YNY7 A0A8I5KXV4 P08397
PDB IDs		5JI7 5JI9 5JIU 7NSC	3ECR 3EQ1 5M6R 5M7F 7AAJ 7AAK 7CCX 7CCY 7CCZ 7CD0 8PND
Enriched GO Terms of Interacting Partners?		Developmental Process Cellular Developmental Process Animal Organ Development Regulation Of Programmed Cell Death Nucleoplasm Protein-containing Complex Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Nuclear Receptor Activity Enzyme Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Biological Quality Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Protein Kinase Binding Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Molecular Condensate Scaffold Activity Cell Surface Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Response To Stress Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Programmed Cell Death Ubiquitin Protein Ligase Binding Chromatin Binding Regulation Of Growth Apoptotic Signaling Pathway	Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid Precursor Protein Catabolic Process Signaling Receptor Binding Positive Regulation Of Receptor Internalization Neuron Projection Organization Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Regulation Of Carbohydrate Catabolic Process Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway G Protein-coupled Receptor Binding Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor Internalization Glial Cell Development Negative Regulation Of UDP-glucose Catabolic Process Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of MiRNA Metabolic Process Modulation Of Chemical Synaptic Transmission Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Establishment Of Protein Localization Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signaling Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Regulation Of Programmed Cell Death Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Cell Communication Regulation Of MAPK Cascade Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Presynaptic Membrane Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission
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