SORL1 and GGA2

Number of citations of the paper that reports this interaction (PMID 11821067)
25

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SORL1	GGA2
Gene Name		sortilin-related receptor, L(DLR class) A repeats containing	golgi-associated, gamma adaptin ear containing, ARF binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Integral Component Of Plasma Membrane Membrane Golgi Cisterna Low-density Lipoprotein Particle Neuronal Cell Body Recycling Endosome Extracellular Vesicular Exosome	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin Adaptor Complex Clathrin-coated Vesicle
	Molecular Function	Beta-amyloid Binding Transmembrane Signaling Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding ADP-ribosylation Factor Binding	Protein Binding ADP-ribosylation Factor Binding
	Biological Process	Protein Targeting To Golgi Protein Targeting Protein Targeting To Lysosome Lipid Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Signal Transduction Cholesterol Metabolic Process Cell Proliferation Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Protein Binding Negative Regulation Of Protein Oligomerization Negative Regulation Of MAP Kinase Activity Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Negative Regulation Of Neurogenesis Protein Maturation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Neuron Death Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Choline O-acetyltransferase Activity Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Endocytic Recycling	Intracellular Protein Transport Vesicle-mediated Transport
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 23565137) Cardiovascular disease risk factors ( 20838585)
Protein-Protein Interactions		5 interactors: FURIN GGA1 GGA2 LRPAP1 PPP1CA	30 interactors: AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC GGA1 GGA3 HGS HTT IGF2R LRP3 M6PR PIN1 RAB5A RABEP1 RABGEF1 RNF11 SORL1 SORT1 SPG21 STAB1 SYNRG TRIM23 VPS18
Entrez ID		6653	23062
HPRD ID		03595	09347
Ensembl ID		ENSG00000137642	ENSG00000103365
Uniprot IDs		E9PP43 Q92673	Q9UJY4
PDB IDs		2DM4 3G2S 3G2T	1MHQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Nerve Growth Factor Production Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Nerve Growth Factor Processing Positive Regulation Of Protein Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Beta-amyloid Clearance Regulation Of Glycogen Catabolic Process Vesicle-mediated Transport Viral Protein Processing Regulation Of Protein Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Extracellular Negative Regulation Of Signal Transduction Signal Peptide Processing Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Virion Assembly Establishment Of Localization In Cell Negative Regulation Of Receptor Activity Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptide Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peptide Hormone Processing Transport Regulation Of Glycogen Metabolic Process Cellular Localization Negative Regulation Of Protein Binding Glycogen Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Intracellular Protein Transport Collagen Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Cellular Protein Catabolic Process Circadian Regulation Of Gene Expression	Vesicle-mediated Transport Endocytosis Intracellular Transport Protein Transport Establishment Of Protein Localization Transport Establishment Of Localization In Cell Protein Localization Cellular Localization Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Lysosomal Transport Golgi Vesicle Transport Vacuolar Transport Cellular Protein Localization Endosomal Transport Regulation Of Vesicle-mediated Transport Endosome To Lysosome Transport Cytoplasmic Transport Visual Learning Membrane Organization Visual Behavior Protein Targeting To Lysosome Protein Localization To Lysosome Associative Learning Cellular Copper Ion Homeostasis Membrane Protein Ectodomain Proteolysis Signaling Protein Targeting To Vacuole Copper Ion Homeostasis Cell Communication Negative Regulation Of Signaling Establishment Of Protein Localization To Vacuole Learning Transition Metal Ion Homeostasis Membrane Protein Proteolysis Regulation Of Exocytosis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Synaptic Plasticity Regulation Of Protein Catabolic Process Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Phosphorylation Neural Plate Formation Negative Regulation Of Kit Signaling Pathway Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Tau-protein Kinase Activity Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Choline O-acetyltransferase Activity
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sporadic triggers turn unlikely	addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sporadic triggers turn unlikely	addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true
Tagcloud (Intersection) ?