SORL1 and PPP1CA

Number of citations of the paper that reports this interaction (PMID 22321011)
2

Data Source:
BioGRID (two hybrid)

		SORL1	PPP1CA
Gene Name		sortilin-related receptor, L(DLR class) A repeats containing	protein phosphatase 1, catalytic subunit, alpha isozyme
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Integral Component Of Plasma Membrane Membrane Golgi Cisterna Low-density Lipoprotein Particle Neuronal Cell Body Recycling Endosome Extracellular Vesicular Exosome	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Glycogen Granule Dendritic Spine Perikaryon Extracellular Vesicular Exosome MLL5-L Complex PTW/PP1 Phosphatase Complex
	Molecular Function	Beta-amyloid Binding Transmembrane Signaling Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding ADP-ribosylation Factor Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Phosphatase Activity Ribonucleoprotein Complex Binding Metal Ion Binding
	Biological Process	Protein Targeting To Golgi Protein Targeting Protein Targeting To Lysosome Lipid Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Signal Transduction Cholesterol Metabolic Process Cell Proliferation Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Protein Binding Negative Regulation Of Protein Oligomerization Negative Regulation Of MAP Kinase Activity Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Negative Regulation Of Neurogenesis Protein Maturation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Neuron Death Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Choline O-acetyltransferase Activity Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Endocytic Recycling	Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Protein Dephosphorylation Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Triglyceride Catabolic Process Lung Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Small Molecule Metabolic Process Branching Morphogenesis Of An Epithelial Tube Cell Division Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Loss of Function of TGFBR2 in Cancer Signaling by GPCR TGFBR2 MSI Frameshift Mutants in Cancer Metabolism of lipids and lipoproteins SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Opioid Signalling TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Lipid digestion, mobilization, and transport TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis DARPP-32 events SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 23565137) Cardiovascular disease risk factors ( 20838585)
Protein-Protein Interactions		5 interactors: FURIN GGA1 GGA2 LRPAP1 PPP1CA	148 interactors: AATK AKAP1 AKAP11 AKAP9 AKT1 APAF1 AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CASC5 CAV1 CCDC181 CD2BP2 CDC5L CDH1 CEP170 CKB CLCN2 CLTC CNP CNST CNTN1 CREB1 CRK CSNK1E CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 EED EIF2AK2 FRMPD4 FXYD1 GLIPR1L2 GLTSCR2 GPKOW H2AFX HEYL HSPA4 IBTK ID2 JPH3 KANK1 KCNQ1 KCTD20 KIAA1377 KIF13A KIF18A LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MIIP MPHOSPH10 MST1R MYO16 NCAM1 NDP NEK2 NOC2L NOM1 NONO PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R2P3 PPP1R2P9 PPP1R32 PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R8 PPP1R9A PPP1R9B PPP2CA PREX1 PRKCB PRKCD PRR16 PTEN RANBP9 RB1 RIF1 RPRD2 SFPQ SFRP1 SH3RF2 SKP1 SLC45A1 SNCAIP SORL1 SPRED1 STAM STAU1 SYTL2 TCTEX1D4 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TUSC3 UBE2Z ULK1 VDR WBP11 WDR82 WWTR1 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827
Entrez ID		6653	5499
HPRD ID		03595	15942
Ensembl ID		ENSG00000137642	ENSG00000172531
Uniprot IDs		E9PP43 Q92673	P62136
PDB IDs		2DM4 3G2S 3G2T	3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Nerve Growth Factor Production Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Nerve Growth Factor Processing Positive Regulation Of Protein Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Beta-amyloid Clearance Regulation Of Glycogen Catabolic Process Vesicle-mediated Transport Viral Protein Processing Regulation Of Protein Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Extracellular Negative Regulation Of Signal Transduction Signal Peptide Processing Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Virion Assembly Establishment Of Localization In Cell Negative Regulation Of Receptor Activity Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptide Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peptide Hormone Processing Transport Regulation Of Glycogen Metabolic Process Cellular Localization Negative Regulation Of Protein Binding Glycogen Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Intracellular Protein Transport Collagen Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Cellular Protein Catabolic Process Circadian Regulation Of Gene Expression	Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphatase Activity Regulation Of Dephosphorylation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Phosphatase Activity Apoptotic Process Negative Regulation Of Dephosphorylation Regulation Of Cellular Component Organization Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process Cell Death Negative Regulation Of Cellular Metabolic Process Death Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Cell Cycle Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Cell Cycle Process Regulation Of Phosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Organelle Organization Intracellular Signal Transduction Regulation Of Protein Phosphorylation Mitotic Cell Cycle Process Regulation Of Organelle Organization Cellular Response To Stress Mitotic Cell Cycle Positive Regulation Of Protein Modification Process Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Differentiation Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Protein Kinase Activity Developmental Process Positive Regulation Of Catalytic Activity Multicellular Organismal Development Anatomical Structure Development Negative Regulation Of Kinase Activity
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sporadic triggers turn unlikely	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sporadic triggers turn unlikely	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau prkdc resequencing rnf168 sanger sl slv smyth stab2 ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Intersection) ?