SORL1 and LRPAP1

Number of citations of the paper that reports this interaction (PMID 8940146)
40

Data Source:
HPRD (in vitro, in vivo)

		SORL1	LRPAP1
Gene Name		sortilin-related receptor, L(DLR class) A repeats containing	low density lipoprotein receptor-related protein associated protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Integral Component Of Plasma Membrane Membrane Golgi Cisterna Low-density Lipoprotein Particle Neuronal Cell Body Recycling Endosome Extracellular Vesicular Exosome	Extracellular Region Endoplasmic Reticulum Plasma Membrane Cell Surface Integral Component Of Membrane Vesicle Rough Endoplasmic Reticulum Lumen
	Molecular Function	Beta-amyloid Binding Transmembrane Signaling Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding ADP-ribosylation Factor Binding	Asialoglycoprotein Receptor Activity Protein Binding Heparin Binding Lipase Binding Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Protein Targeting To Golgi Protein Targeting Protein Targeting To Lysosome Lipid Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Signal Transduction Cholesterol Metabolic Process Cell Proliferation Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Protein Binding Negative Regulation Of Protein Oligomerization Negative Regulation Of MAP Kinase Activity Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Negative Regulation Of Neurogenesis Protein Maturation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Negative Regulation Of Neuron Death Negative Regulation Of Beta-amyloid Formation Positive Regulation Of Choline O-acetyltransferase Activity Negative Regulation Of Tau-protein Kinase Activity Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Endocytic Recycling	Protein Folding Receptor-mediated Endocytosis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Vesicle-mediated Transport Negative Regulation Of Protein Binding Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Beta-amyloid Clearance
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 23565137) Cardiovascular disease risk factors ( 20838585)
Protein-Protein Interactions		5 interactors: FURIN GGA1 GGA2 LRPAP1 PPP1CA	18 interactors: ETV7 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALA RALGDS RANBP2 RTN4 SORL1 SORT1 VLDLR
Entrez ID		6653	4043
HPRD ID		03595	00082
Ensembl ID		ENSG00000137642
Uniprot IDs		E9PP43 Q92673	P30533
PDB IDs		2DM4 3G2S 3G2T	1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Nerve Growth Factor Production Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Transforming Growth Factor Beta1 Production Negative Regulation Of Receptor Catabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Nerve Growth Factor Processing Positive Regulation Of Protein Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Beta-amyloid Clearance Regulation Of Glycogen Catabolic Process Vesicle-mediated Transport Viral Protein Processing Regulation Of Protein Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Peptidyl-glutamic Acid Carboxylation Extracellular Negative Regulation Of Signal Transduction Signal Peptide Processing Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Virion Assembly Establishment Of Localization In Cell Negative Regulation Of Receptor Activity Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptide Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Peptide Hormone Processing Transport Regulation Of Glycogen Metabolic Process Cellular Localization Negative Regulation Of Protein Binding Glycogen Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Intracellular Protein Transport Collagen Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Cellular Protein Catabolic Process Circadian Regulation Of Gene Expression	Receptor-mediated Endocytosis Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Phototransduction, Visible Light Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Retinoid Metabolic Process Transport Ras Protein Signal Transduction Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Signal Transduction Regulation Of Kinase Activity Steroid Metabolic Process Detection Of Light Stimulus Cholesterol Metabolic Process Signaling Isoprenoid Metabolic Process Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Sterol Metabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Golgi Inheritance Regulation Of Cellular Component Organization Alcohol Metabolic Process Caveolin-mediated Endocytosis Regulation Of Phosphorus Metabolic Process Detection Of Abiotic Stimulus Response To Abiotic Stimulus Reelin-mediated Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Golgi Organization Cellular Response To Stimulus Activation Of MAPKK Activity Positive Regulation Of Protein Kinase Activity Locomotion Response To External Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorylation Response To Organic Substance Regulation Of Early Endosome To Late Endosome Transport Viral Process
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sporadic triggers turn unlikely
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sporadic triggers turn unlikely
Tagcloud (Intersection) ?