SORL1 and LRPAP1

Number of citations of the paper that reports this interaction (PubMedID 8940146)
0

Data Source:
HPRD (in vitro, in vivo)

		SORL1	LRPAP1
Description		sortilin related receptor 1	LDL receptor related protein associated protein 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Golgi Cisterna Multivesicular Body Membrane Neuronal Cell Body Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Perinucleolar Compartment	Extracellular Region Endosome Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi Lumen Cis-Golgi Network Plasma Membrane Cell Surface Endomembrane System Endosome Lumen Vesicle Rough Endoplasmic Reticulum Lumen
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Low-density Lipoprotein Particle Binding Small GTPase Binding Neuropeptide Binding Protein Transporter Activity	Amyloid-beta Binding Signaling Receptor Binding Protein Binding Heparin Binding Lipase Binding Receptor Ligand Activity Receptor Antagonist Activity Low-density Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Diet Induced Thermogenesis Protein Targeting Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Neuropeptide Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Protein Localization To Golgi Apparatus Amyloid-beta Formation Insulin Receptor Recycling Retrograde Transport, Endosome To Golgi Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Neurogenesis Positive Regulation Of Protein Exit From Endoplasmic Reticulum Endosome To Plasma Membrane Protein Transport Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Amyloid-beta Formation Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Adipose Tissue Development Adaptive Thermogenesis Positive Regulation Of Endocytic Recycling	Negative Regulation Of Receptor Internalization Signal Transduction Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Receptor-mediated Endocytosis Amyloid-beta Clearance By Transcytosis Extracellular Negative Regulation Of Signal Transduction Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Clearance
Pathways		Amyloid fiber formation
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 23565137 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Atrial fibrillation ( 30061737 29892015) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Cadmium levels ( 26025379) Cardiovascular risk factors (age interaction) ( 20838585) Estimated glomerular filtration rate ( 31152163 31451708) Family history of Alzheimer's disease ( 30617256) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Mood disorder in prion disease ( 25897833) Non-word reading ( 30741946) Problematic alcohol use ( 32451486) Rheumatic heart disease ( 34106200) Smoking status (ever vs never smokers) ( 30643258) Spontaneous preterm birth (preterm birth) ( 25599974) Word reading ( 30741946)	Cholesterol, total ( 24097068 25961943) Fibrinogen ( 23969696) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943) Tuberculosis ( 29036319)
Interacting Genes		12 interacting genes: APOE ERBB2 ERBB3 FURIN GGA1 GGA2 HSPA12A LRPAP1 POU6F2 PPP1CA RHOH SORT1	21 interacting genes: ASPH ETV7 IFNAR1 LDLR LRP1 LRP1B LRP2 LRP8 MAPK1 MAPK3 POLA2 PPM1G RAF1 RALGDS RANBP2 RTN4 SNCA SORL1 SORT1 TTC3 VLDLR
Entrez ID		6653	4043
HPRD ID		03595	00082
Ensembl ID		ENSG00000137642	ENSG00000163956
Uniprot IDs		Q92673	P30533
PDB IDs		2DM4 3G2S 3G2T 3WSX 3WSY 3WSZ 7VT0	1LRE 1NRE 1OP1 1OV2 2FCW 2FTU 2FYL 2P01 2P03
Enriched GO Terms of Interacting Partners?		Endosome ERBB3:ERBB2 Complex Endosome Membrane Very-low-density Lipoprotein Particle Receptor Binding ErbB-3 Class Receptor Binding Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Amyloid-beta Clearance ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Protein Localization To Membrane Post-Golgi Vesicle-mediated Transport Early Endosome Positive Regulation Of Membrane Protein Ectodomain Proteolysis Trans-Golgi Network Transport Vesicle Schwann Cell Development Regulation Of Amyloid-beta Clearance ERBB2 Signaling Pathway Golgi Apparatus Low-density Lipoprotein Particle Receptor Binding Regulation Of Membrane Protein Ectodomain Proteolysis Peripheral Nervous System Development Heparin Binding Protein Localization To Cell Surface Cellular Localization Plasma Lipoprotein Particle Remodeling Trans-Golgi Network Golgi To Plasma Membrane Protein Transport Protein-containing Complex Remodeling Localization Within Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Growth Factor Binding Protein Localization To Cell Periphery Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Neurotensin Receptor Activity, Non-G Protein-coupled Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Intracellular Transport Enzyme-linked Receptor Protein Signaling Pathway Golgi To Plasma Membrane Transport Golgi Vesicle Transport	Low-density Lipoprotein Particle Receptor Activity Endocytosis Import Into Cell Receptor-mediated Endocytosis Receptor Complex Very-low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Cargo Receptor Activity Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Lysosomal Protein Catabolic Process Calcium Ion Binding Apolipoprotein Binding Pseudopodium Reelin Receptor Activity Schwann Cell Development Retinoid Metabolic Process Early Endosome Diterpenoid Metabolic Process Protein Transport Face Development Plasma Membrane ERBB2 Signaling Pathway Amyloid-beta Metabolic Process Amyloid-beta Binding Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Amyloid-beta Clearance Interleukin-34-mediated Signaling Pathway Terpenoid Metabolic Process Positive Regulation Of Macrophage Migration Thyroid Gland Development Isoprenoid Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Golgi Inheritance Establishment Of Protein Localization Positive Regulation Of Protein Localization Golgi Apparatus Positive Regulation Of Defense Response Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Intracellular Transport Regulation Of Neuroinflammatory Response Intracellular Protein Localization Regulation Of Macrophage Migration Anatomical Structure Morphogenesis Regulation Of Cellular Localization
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