SORL1 and RHOH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SORL1	RHOH
Description		sortilin related receptor 1	ras homolog family member H
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Golgi Cisterna Multivesicular Body Membrane Neuronal Cell Body Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Perinucleolar Compartment	Immunological Synapse Cytoplasm Plasma Membrane Membrane
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Low-density Lipoprotein Particle Binding Small GTPase Binding Neuropeptide Binding Protein Transporter Activity	Nucleotide Binding GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding Kinase Inhibitor Activity Protein Kinase Binding Small GTPase Binding
	Biological Process	Diet Induced Thermogenesis Protein Targeting Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Neuropeptide Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Protein Localization To Golgi Apparatus Amyloid-beta Formation Insulin Receptor Recycling Retrograde Transport, Endosome To Golgi Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Neurogenesis Positive Regulation Of Protein Exit From Endoplasmic Reticulum Endosome To Plasma Membrane Protein Transport Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Amyloid-beta Formation Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Adipose Tissue Development Adaptive Thermogenesis Positive Regulation Of Endocytic Recycling	Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction T Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Mast Cell Activation Positive Regulation Of T Cell Differentiation
Pathways		Amyloid fiber formation	RHOH GTPase cycle
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 23565137 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Atrial fibrillation ( 30061737 29892015) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Cadmium levels ( 26025379) Cardiovascular risk factors (age interaction) ( 20838585) Estimated glomerular filtration rate ( 31152163 31451708) Family history of Alzheimer's disease ( 30617256) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Mood disorder in prion disease ( 25897833) Non-word reading ( 30741946) Problematic alcohol use ( 32451486) Rheumatic heart disease ( 34106200) Smoking status (ever vs never smokers) ( 30643258) Spontaneous preterm birth (preterm birth) ( 25599974) Word reading ( 30741946)	Graves' disease ( 21841780) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		12 interacting genes: APOE ERBB2 ERBB3 FURIN GGA1 GGA2 HSPA12A LRPAP1 POU6F2 PPP1CA RHOH SORT1	23 interacting genes: ARHGDIA ARHGDIB ARHGDIG BANP CCNH FAM90A1 GDI1 IQUB ITGB1BP1 KANK2 KCNH2 LRIF1 MBLAC1 MTX2 PLEKHA7 RIPPLY1 SCNM1 SORL1 SUOX TCF19 TGFBR1 UTP14A XPNPEP1
Entrez ID		6653	399
HPRD ID		03595	03616
Ensembl ID		ENSG00000137642	ENSG00000168421
Uniprot IDs		Q92673	Q15669 Q6ICP4
PDB IDs		2DM4 3G2S 3G2T 3WSX 3WSY 3WSZ 7VT0
Enriched GO Terms of Interacting Partners?		Endosome ERBB3:ERBB2 Complex Endosome Membrane Very-low-density Lipoprotein Particle Receptor Binding ErbB-3 Class Receptor Binding Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Amyloid-beta Clearance ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Protein Localization To Membrane Post-Golgi Vesicle-mediated Transport Early Endosome Positive Regulation Of Membrane Protein Ectodomain Proteolysis Trans-Golgi Network Transport Vesicle Schwann Cell Development Regulation Of Amyloid-beta Clearance ERBB2 Signaling Pathway Golgi Apparatus Low-density Lipoprotein Particle Receptor Binding Regulation Of Membrane Protein Ectodomain Proteolysis Peripheral Nervous System Development Heparin Binding Protein Localization To Cell Surface Cellular Localization Plasma Lipoprotein Particle Remodeling Trans-Golgi Network Golgi To Plasma Membrane Protein Transport Protein-containing Complex Remodeling Localization Within Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Growth Factor Binding Protein Localization To Cell Periphery Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Neurotensin Receptor Activity, Non-G Protein-coupled Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Intracellular Transport Enzyme-linked Receptor Protein Signaling Pathway Golgi To Plasma Membrane Transport Golgi Vesicle Transport	Rho GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Targeting To Membrane Rho Protein Signal Transduction
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