SORL1 and ERBB3

Number of citations of the paper that reports this interaction (PubMedID 33420373)
65

Data Source:
BioGRID (pull down)

		SORL1	ERBB3
Description		sortilin related receptor 1	erb-b2 receptor tyrosine kinase 3
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Nuclear Envelope Lumen Endosome Early Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Golgi Cisterna Multivesicular Body Membrane Neuronal Cell Body Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Perinucleolar Compartment	Extracellular Region Extracellular Space Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex
	Molecular Function	Amyloid-beta Binding Transmembrane Signaling Receptor Activity Low-density Lipoprotein Particle Receptor Activity Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Low-density Lipoprotein Particle Binding Small GTPase Binding Neuropeptide Binding Protein Transporter Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neuregulin Receptor Activity Neuregulin Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	Diet Induced Thermogenesis Protein Targeting Protein Targeting To Lysosome Post-Golgi Vesicle-mediated Transport Endocytosis Receptor-mediated Endocytosis Neuropeptide Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Protein Localization To Golgi Apparatus Amyloid-beta Formation Insulin Receptor Recycling Retrograde Transport, Endosome To Golgi Protein Retention In Golgi Apparatus Positive Regulation Of Protein Catabolic Process Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Neurogenesis Positive Regulation Of Protein Exit From Endoplasmic Reticulum Endosome To Plasma Membrane Protein Transport Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Amyloid-beta Formation Positive Regulation Of ER To Golgi Vesicle-mediated Transport Positive Regulation Of Early Endosome To Recycling Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Adipose Tissue Development Adaptive Thermogenesis Positive Regulation Of Endocytic Recycling	Endocardial Cushion Development Negative Regulation Of Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Schwann Cell Differentiation Schwann Cell Development Cranial Nerve Development Neuron Differentiation ERBB2-ERBB3 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Myelination Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Amyloid fiber formation
Drugs			Tucatinib
Diseases			Type I diabetes mellitus Lethal congenital contractural syndrome (LCCS)
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 23565137 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Atrial fibrillation ( 30061737 29892015) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Cadmium levels ( 26025379) Cardiovascular risk factors (age interaction) ( 20838585) Estimated glomerular filtration rate ( 31152163 31451708) Family history of Alzheimer's disease ( 30617256) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Mood disorder in prion disease ( 25897833) Non-word reading ( 30741946) Problematic alcohol use ( 32451486) Rheumatic heart disease ( 34106200) Smoking status (ever vs never smokers) ( 30643258) Spontaneous preterm birth (preterm birth) ( 25599974) Word reading ( 30741946)	Age at first sexual intercourse ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29785011) Alopecia areata ( 25608926) Anorexia nervosa ( 28494655) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Body mass index ( 32700739) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Household income (MTAG) ( 31844048) Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Smoking initiation ( 33082346 30617275) Type 1 diabetes ( 17554300 18198356 18978792 19430480 21829393 30572963 17554260) Vitiligo ( 22951725)
Interacting Genes		12 interacting genes: APOE ERBB2 ERBB3 FURIN GGA1 GGA2 HSPA12A LRPAP1 POU6F2 PPP1CA RHOH SORT1	196 interacting genes: ABL1 ABL2 ACYP1 AGTR2 ALDOA ATP5ME BCAR3 BEND5 BLK BLNK BTK CALM1 CD82 CDC25C CDK5 CFL1 CHN2 CRK CRKL CSPG5 DAB1 DAPP1 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DYRK1A EGF EGFR EGR1 ENOPH1 ERBB2 ERBB4 ERG28 EYA4 EZR FAM241B FER FES FGFR1 FGR FHL3 FKBP1A FLNA FLYWCH1 GABARAPL1 GABARAPL2 GRAP2 GRB2 GRB7 HCK HDAC6 HINT1 HSH2D HSPA1A HSPA8 IL6ST ILKAP INPPL1 IRF2BP2 ITK JAK2 JAK3 JUP LAMTOR2 LBHD1 LCK LCP2 LRRC7 LYN MAP1B MATK MTMR1 MTMR10 MTMR2 MTMR6 MTMR8 MTMR9 MUC1 MUC4 MYCBP MYCBP2 NCK1 NCK2 NDUFAB1 NEDD4 NRG1 NRG2 NSMCE1 ODF2L PA2G4 PDGFRA PFDN2 PFDN4 PHPT1 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PPM1K PPM1M PRDX5 PRKACA PRRG4 PSMA5 PTEN PTGES3 PTK2 PTK2B PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRH PTPRR RALGAPA1 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 RTN4 RWDD2A S100A10 SAP18 SELENOK SF3B6 SH2B1 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNCA SNRPB2 SOCS2 SOCS3 SOCS5 SOCS6 SORL1 SOS1 SRC SRPK2 STAP1 STYX SYK SYNM TBCA TCEA2 TEC TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TPTE TRIR TVP23B TXK TXN TXNL4A VAV1 VAV2 VAV3 VTA1 WRNIP1 YES1 YWHAZ ZAP70 ZNF207 ZNF532
Entrez ID		6653	2065
HPRD ID		03595	01820
Ensembl ID		ENSG00000137642	ENSG00000065361
Uniprot IDs		Q92673	P21860
PDB IDs		2DM4 3G2S 3G2T 3WSX 3WSY 3WSZ 7VT0	1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4P59 4RIW 4RIX 4RIY 5CUS 5O4O 5O7P 6KBI 6OP9 7BHE 7BHF 7D85 7MN5 7MN6 7MN8
Enriched GO Terms of Interacting Partners?		Endosome ERBB3:ERBB2 Complex Endosome Membrane Very-low-density Lipoprotein Particle Receptor Binding ErbB-3 Class Receptor Binding Nerve Growth Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Amyloid-beta Clearance ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Protein Localization To Membrane Post-Golgi Vesicle-mediated Transport Early Endosome Positive Regulation Of Membrane Protein Ectodomain Proteolysis Trans-Golgi Network Transport Vesicle Schwann Cell Development Regulation Of Amyloid-beta Clearance ERBB2 Signaling Pathway Golgi Apparatus Low-density Lipoprotein Particle Receptor Binding Regulation Of Membrane Protein Ectodomain Proteolysis Peripheral Nervous System Development Heparin Binding Protein Localization To Cell Surface Cellular Localization Plasma Lipoprotein Particle Remodeling Trans-Golgi Network Golgi To Plasma Membrane Protein Transport Protein-containing Complex Remodeling Localization Within Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Phospholipid Efflux Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Growth Factor Binding Protein Localization To Cell Periphery Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Neurotensin Receptor Activity, Non-G Protein-coupled Establishment Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Intracellular Transport Enzyme-linked Receptor Protein Signaling Pathway Golgi To Plasma Membrane Transport Golgi Vesicle Transport	Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity ERBB Signaling Pathway Intracellular Signal Transduction Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Cytosol Regulation Of Signaling Regulation Of Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Phosphate-containing Compound Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Protein Tyrosine Phosphatase Activity Dephosphorylation Regulation Of Immune Response Cell Activation Leukocyte Activation Cytoplasm Antigen Receptor-mediated Signaling Pathway Protein Phosphorylation Protein Modification Process Immune Response-activating Signaling Pathway Regulation Of Cell Adhesion Protein Kinase Activity Positive Regulation Of Signal Transduction Phosphorylation Immune Response-regulating Signaling Pathway Protein Dephosphorylation Positive Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell Migration Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune Response Lymphocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Regulation Of Immune System Process
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