PRPF6 and CD2BP2

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		PRPF6	CD2BP2
Gene Name		pre-mRNA processing factor 6	CD2 (cytoplasmic tail) binding protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Membrane Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm U5 SnRNP Cytoplasm Nuclear Speck U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Binding Ribonucleoprotein Complex Binding Poly(A) RNA Binding Androgen Receptor Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Localization RNA Splicing Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression Negative Regulation Of Phosphatase Activity
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		13 interactors: AR ARAF CD2BP2 EFTUD2 ESR1 NR3C1 RAF1 SMARCA2 SRRM2 TIMM44 TXNL4A TXNL4B YWHAB	11 interactors: AKNA CD2 CSNK2A1 PPP1CA PPP1CC PRPF6 PSMF1 SMU1 SNRPB TXNL4A WBP11
Entrez ID		24148	10421
HPRD ID		10729	05127
Ensembl ID		ENSG00000101161	ENSG00000169217
Uniprot IDs		O94906	O95400
PDB IDs			1GYF 1L2Z 1SYX
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Gene Expression MRNA Processing Intracellular Steroid Hormone Receptor Signaling Pathway RNA Metabolic Process MRNA Metabolic Process Cellular Response To Hormone Stimulus RNA Processing Cellular Metabolic Process Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Response To Hormone Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Ribonucleoprotein Complex Assembly Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Initiation Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Mammary Gland Duct Morphogenesis Spliceosomal Complex Assembly Nitrogen Compound Metabolic Process Organelle Organization Death-inducing Signaling Complex Assembly Negative Regulation Of Integrin Biosynthetic Process Glucocorticoid Mediated Signaling Pathway Activation Of MAPKK Activity Negative Regulation Of Dephosphorylation Prostate Gland Development Ribonucleoprotein Complex Biogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Metabolic Process Mammary Gland Morphogenesis Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Positive Regulation Of Cellular Biosynthetic Process Aortic Smooth Muscle Cell Differentiation Mammary Gland Epithelium Development Cellular Response To Lipid	Ribonucleoprotein Complex Biogenesis RNA Splicing MRNA Processing Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Ribonucleoprotein Complex Assembly MRNA Metabolic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression Cell Cycle Spliceosomal SnRNP Assembly Mitotic Cell Cycle Rhythmic Process Glycogen Metabolic Process Spliceosomal Complex Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Cellular Protein Catabolic Process Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Cell Division Triglyceride Metabolic Process Regulation Of Circadian Rhythm RNA Metabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Membrane Raft Polarization Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Interferon-gamma Secretion Cellular Lipid Catabolic Process Positive Regulation Of Wnt Signaling Pathway Cellular Macromolecular Complex Assembly Membrane Raft Localization Mitotic Cell Cycle Checkpoint Nitrogen Compound Metabolic Process Circadian Rhythm Mitotic Cell Cycle Process Regulation Of Myeloid Dendritic Cell Activation
Tagcloud ?			24h 48h anova aureus bcap31 caprine challenged chemotactic cxcl6 dairy fosl2 goats granulocyte halves ilt5 infused intramammary intricacy junb lymphotoxin mapk13 mastitis mhcii microarrays mscs pbs udder udders veterinary
Tagcloud (Difference) ?			24h 48h anova aureus bcap31 caprine challenged chemotactic cxcl6 dairy fosl2 goats granulocyte halves ilt5 infused intramammary intricacy junb lymphotoxin mapk13 mastitis mhcii microarrays mscs pbs udder udders veterinary
Tagcloud (Intersection) ?