PRPF6 and FHIT

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRPF6	FHIT
Description		pre-mRNA processing factor 6	fragile histidine triad diadenosine triphosphatase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Centrosome Cytosol Membrane Nuclear Speck Ciliary Basal Body U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Fibrillar Center Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding	Nucleotide Binding Catalytic Activity Protein Binding Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Adenosine 5'-monophosphoramidase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Adenylylsulfatase Activity Bis(5'-adenosyl)-triphosphatase Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Localization RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II	Purine Nucleotide Metabolic Process Apoptotic Process Diadenosine Triphosphate Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs			Adenosine monotungstate Ado-P-Ch2-P-Ps-Ado
Diseases			Small cell lung cancer Non-small cell lung cancer
GWAS		Body mass index ( 28552196) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Prostate cancer ( 23535732) Refractive error ( 32231278)	Adult body size ( 32376654) Adverse response to lamotrigine and phenytoin ( 22379998) Age at first sexual intercourse ( 34211149) Aortic root size ( 21223598) Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 24954895) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28892062 28552196 28448500 26961502 25673413) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Broad depression or schizophrenia ( 30626913) Bronchopulmonary dysplasia ( 23897914) Caudal anterior-cingulate cortex volume ( 31530798) Cognitive function ( 25644384) Conotruncal heart defects ( 24800985) Depressive symptom measurement or major depressive disorder ( 28049566) Differentiated thyroid cancer ( 28703219) Falling risk ( 32999390) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hip circumference ( 28552196) Intracranial aneurysm ( 29531279) Iris color (L* coordinate) ( 30895295) Irritable bowel syndrome ( 29673008) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lung function (maximal voluntary ventilation) ( 29095316) Major coronary event in cardiovascular disease (time to event) (darapladib treatment interaction) ( 28753643) Major coronary event in placebo-treated cardiovascular disease (time to event) ( 28753643) Major depressive disorder ( 20125088) Methadone dose in opioid dependence ( 28115739) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Papillary thyroid cancer ( 28703219) Pars triangularis volume ( 31530798) Photic sneeze reflex ( 27182965) Postoperative myocardial infarction after cardiac surgery ( 30678657) Refractive error ( 32231278) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553) Schizophrenia ( 30285260) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Urinary metabolite levels in chronic kidney disease ( 29545352) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		67 interacting genes: AR ARAF BAG4 BICD2 C1orf35 CD2BP2 CEBPA CEP55 CLK2 CPSF7 CTBP1 CTTN DDX17 DMRTB1 EFTUD2 EHMT2 ESR1 EXOSC7 EXOSC8 FHIT FXR2 HNRNPLL HOOK1 IDH3A KIF24 KRT31 LARP4 LMNA MRPL1 MRPL44 MRPS11 NIN NME1 NR3C1 PCM1 PHF5A PPIE QKI RAF1 RBM22 RBPMS RNF10 RPL36AL RYBP SF3B4 SMARCA2 SNRNP200 SNRNP48 SNRNP70 SNRPA SNRPF SRRM2 SRSF2 SRSF8 SUMO2 SUN2 TFIP11 THOC1 TIMM44 TRAK1 TRMT1L TSNAXIP1 TXNL4B USO1 VIM YWHAB ZRSR2	13 interacting genes: BCAS2 CTNNB1 DDIT4L FDXR GSN HSPD1 PRPF6 RAB40B REL SRC TRIM23 UBE2I YTHDF1
Entrez ID		24148	2272
HPRD ID		10729	03096
Ensembl ID		ENSG00000101161	ENSG00000189283
Uniprot IDs		O94906	P49789
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT 7P8P
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Metabolic Process Nucleic Acid Binding Nuclear Speck Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Nucleoplasm Regulation Of RNA Splicing U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Protein Binding Identical Protein Binding U2-type Catalytic Step 2 Spliceosome U5 SnRNP Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Estrogen Response Element Binding Regulation Of MRNA Processing Microtubule Anchoring At Microtubule Organizing Center Spliceosomal Complex Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing U1 SnRNP Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Microtubule Anchoring U2-type Prespliceosome Assembly Protein-RNA Complex Assembly Nuclear Migration Regulation Of Alternative MRNA Splicing, Via Spliceosome U2 SnRNP Nuclear Matrix Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process U2-type Spliceosomal Complex Steroid Hormone Receptor Signaling Pathway	Bone Resorption Response To Muscle Stretch Oocyte Development Cellular Component Assembly Regulation Of Podosome Assembly Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Post-translational Protein Modification Immune System Process Protein Metabolic Process Germ Cell Development Lamellipodium Enzyme Binding Glial Cell Fate Determination Transcription Coregulator Binding Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Ferredoxin-NADP+ Reductase Activity Response To Cytokine Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Podosome Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Oogenesis Regulation Of Lamellipodium Organization SUMO Conjugating Enzyme Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Response To Peptide Regulation Of Protein Processing Protein Destabilization Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Epidermal Growth Factor Receptor Signaling Pathway Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Protein Catabolic Process Forebrain Development Regulation Of Protein Maturation Positive Regulation Of Protein Processing In Phagocytic Vesicle Female Gamete Generation Protein Modification By Small Protein Conjugation
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