PRPF6 and SRRM2

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		PRPF6	SRRM2
Gene Name		pre-mRNA processing factor 6	serine/arginine repetitive matrix 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Membrane Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP Catalytic Step 2 Spliceosome	Nucleoplasm Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Binding Ribonucleoprotein Complex Binding Poly(A) RNA Binding Androgen Receptor Binding	Poly(A) RNA Binding Protein N-terminus Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Localization RNA Splicing Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	MRNA Splicing, Via Spliceosome
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		13 interactors: AR ARAF CD2BP2 EFTUD2 ESR1 NR3C1 RAF1 SMARCA2 SRRM2 TIMM44 TXNL4A TXNL4B YWHAB	12 interactors: APP CSNK2A1 PIN1 PNN PRPF6 SNIP1 SRRM1 SRSF4 TTC14 XRN1 YWHAB YWHAG
Entrez ID		24148	23524
HPRD ID		10729	06913
Ensembl ID		ENSG00000101161	ENSG00000167978
Uniprot IDs		O94906	Q9UQ35
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Gene Expression MRNA Processing Intracellular Steroid Hormone Receptor Signaling Pathway RNA Metabolic Process MRNA Metabolic Process Cellular Response To Hormone Stimulus RNA Processing Cellular Metabolic Process Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Response To Hormone Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Ribonucleoprotein Complex Assembly Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Initiation Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Mammary Gland Duct Morphogenesis Spliceosomal Complex Assembly Nitrogen Compound Metabolic Process Organelle Organization Death-inducing Signaling Complex Assembly Negative Regulation Of Integrin Biosynthetic Process Glucocorticoid Mediated Signaling Pathway Activation Of MAPKK Activity Negative Regulation Of Dephosphorylation Prostate Gland Development Ribonucleoprotein Complex Biogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Metabolic Process Mammary Gland Morphogenesis Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Positive Regulation Of Cellular Biosynthetic Process Aortic Smooth Muscle Cell Differentiation Mammary Gland Epithelium Development Cellular Response To Lipid	MRNA Metabolic Process RNA Processing MRNA Processing Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA 3'-end Processing RNA Metabolic Process RNA Splicing RNA 3'-end Processing RNA Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Termination Of RNA Polymerase II Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Mitochondrion Organization Cellular Nitrogen Compound Metabolic Process Intracellular Transport Negative Regulation Of Cellular Protein Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination Negative Regulation Of Protein Metabolic Process RNA Export From Nucleus Regulation Of Organelle Organization Axon Guidance Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Mitotic Cell Cycle Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Metabolic Process Synaptic Growth At Neuromuscular Junction Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Process Establishment Of Localization In Cell Regulation Of RNA Metabolic Process Nuclear Export MRNA Transport Cellular Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Mitotic Nuclear Division Axonogenesis Positive Regulation Of Protein Metabolic Process
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