PRPF6 and CEP55

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRPF6	CEP55
Description		pre-mRNA processing factor 6	centrosomal protein 55
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Centrosome Cytosol Membrane Nuclear Speck Ciliary Basal Body U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Cytoplasm Centrosome Centriole Cytoskeleton Membrane Midbody Cleavage Furrow Intercellular Bridge Flemming Body
	Molecular Function	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding	Protein Binding Identical Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Localization RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Chromosome Alignment Establishment Of Protein Localization Cell Division Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Midbody Abscission Cranial Skeletal System Development
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Body mass index ( 28552196) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Prostate cancer ( 23535732) Refractive error ( 32231278)	High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)
Interacting Genes		67 interacting genes: AR ARAF BAG4 BICD2 C1orf35 CD2BP2 CEBPA CEP55 CLK2 CPSF7 CTBP1 CTTN DDX17 DMRTB1 EFTUD2 EHMT2 ESR1 EXOSC7 EXOSC8 FHIT FXR2 HNRNPLL HOOK1 IDH3A KIF24 KRT31 LARP4 LMNA MRPL1 MRPL44 MRPS11 NIN NME1 NR3C1 PCM1 PHF5A PPIE QKI RAF1 RBM22 RBPMS RNF10 RPL36AL RYBP SF3B4 SMARCA2 SNRNP200 SNRNP48 SNRNP70 SNRPA SNRPF SRRM2 SRSF2 SRSF8 SUMO2 SUN2 TFIP11 THOC1 TIMM44 TRAK1 TRMT1L TSNAXIP1 TXNL4B USO1 VIM YWHAB ZRSR2	94 interacting genes: AIRIM AKAP9 ANXA11 ARHGEF15 BAG4 C1orf216 CBY2 CCBE1 CCDC120 CCHCR1 CDC37 CDC45 CDK1 CDSN CEP57L1 CFTR COL8A1 CPSF7 DTNB ECSIT EIF1AD ENKD1 ESS2 EXOSC5 FAM161B FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS HNRNPA0 HSF2BP KANK2 KIFC3 KRT31 LENG1 LGALS4 LRRC23 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NEDD4L NOS3 NTAQ1 NXF1 OGT PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PRPF6 PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RBM42 RBPMS RCOR3 RNF32 SDCBP SF1 SFPQ SNRPB SNRPN SNW1 SS18L1 SUPT5H TCL1A TEAD4 TEX11 TFG TFIP11 TP53BP2 TSG101 UBC VPS37C VPS37D WASHC1 WASHC3 ZNF48
Entrez ID		24148	55165
HPRD ID		10729	12569
Ensembl ID		ENSG00000101161	ENSG00000138180
Uniprot IDs		O94906	Q53EZ4
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O	3E1R 3WUT 3WUU 3WUV
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Metabolic Process Nucleic Acid Binding Nuclear Speck Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Nucleoplasm Regulation Of RNA Splicing U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Protein Binding Identical Protein Binding U2-type Catalytic Step 2 Spliceosome U5 SnRNP Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Estrogen Response Element Binding Regulation Of MRNA Processing Microtubule Anchoring At Microtubule Organizing Center Spliceosomal Complex Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing U1 SnRNP Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Microtubule Anchoring U2-type Prespliceosome Assembly Protein-RNA Complex Assembly Nuclear Migration Regulation Of Alternative MRNA Splicing, Via Spliceosome U2 SnRNP Nuclear Matrix Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process U2-type Spliceosomal Complex Steroid Hormone Receptor Signaling Pathway	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Binding Spliceosomal Complex Centrosome MRNA Processing Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway RNA Splicing Nucleoplasm MRNA Metabolic Process Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Catalytic Step 2 Spliceosome Cytoskeleton Multivesicular Body Assembly Multivesicular Body Organization Positive Regulation Of Exosomal Secretion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway RNA Processing Calcium-dependent Protein Binding RNA Binding Viral Budding Via Host ESCRT Complex Multivesicular Body Sorting Pathway Positive Regulation Of Exocytosis Viral Budding MRNA Binding Protein Localization To Vacuole Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Component Assembly Nucleic Acid Metabolic Process Microtubule Nucleation Cytosol Establishment Of Protein Localization To Vacuole ESCRT I Complex Centriole Cytoplasm Spindle Nucleic Acid Binding U4/U6 X U5 Tri-snRNP Complex Microtubule Cytoskeleton Organization Involved In Mitosis MRNA Cis Splicing, Via Spliceosome SnRNP Binding Endosome Organization Microtubule Organizing Center Organization Membrane Fission Microtubule-based Process Organelle Assembly
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