PRPF6 and TXNL4B

Number of citations of the paper that reports this interaction (PMID 15161931)
5

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PRPF6	TXNL4B
Gene Name		pre-mRNA processing factor 6	thioredoxin-like 4B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Membrane Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP Catalytic Step 2 Spliceosome	Spliceosomal Complex U5 SnRNP U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Transcription Coactivator Activity RNA Binding Protein Binding Ribonucleoprotein Complex Binding Poly(A) RNA Binding Androgen Receptor Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Localization RNA Splicing Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter	Spliceosomal Complex Assembly Mitotic Nuclear Division
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		13 interactors: AR ARAF CD2BP2 EFTUD2 ESR1 NR3C1 RAF1 SMARCA2 SRRM2 TIMM44 TXNL4A TXNL4B YWHAB	6 interactors: BHLHE40 PLEKHF2 PNMA5 PRPF6 REL TCF4
Entrez ID		24148	54957
HPRD ID		10729	11655
Ensembl ID		ENSG00000101161	ENSG00000140830
Uniprot IDs		O94906	Q9NX01
PDB IDs			1XBS 3GIX 4IN0
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Gene Expression MRNA Processing Intracellular Steroid Hormone Receptor Signaling Pathway RNA Metabolic Process MRNA Metabolic Process Cellular Response To Hormone Stimulus RNA Processing Cellular Metabolic Process Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Response To Hormone Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Ribonucleoprotein Complex Assembly Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA-templated Transcription, Initiation Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Mammary Gland Duct Morphogenesis Spliceosomal Complex Assembly Nitrogen Compound Metabolic Process Organelle Organization Death-inducing Signaling Complex Assembly Negative Regulation Of Integrin Biosynthetic Process Glucocorticoid Mediated Signaling Pathway Activation Of MAPKK Activity Negative Regulation Of Dephosphorylation Prostate Gland Development Ribonucleoprotein Complex Biogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Metabolic Process Mammary Gland Morphogenesis Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Positive Regulation Of Cellular Biosynthetic Process Aortic Smooth Muscle Cell Differentiation Mammary Gland Epithelium Development Cellular Response To Lipid	Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Transcription From RNA Polymerase II Promoter Maintenance Of DNA Repeat Elements Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Genitalia Morphogenesis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Myoblast Fate Commitment Negative Regulation Of RNA Biosynthetic Process Secretory Granule Localization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Hindgut Morphogenesis Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Hindgut Development Positive Regulation Of Protein Export From Nucleus Spliceosomal Tri-snRNP Complex Assembly Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Triglyceride Biosynthetic Process RNA Metabolic Process Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Gluconeogenesis Regulation Of Cell Death Regulation Of Triglyceride Biosynthetic Process Genitalia Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Gene Expression Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Embryonic Digestive Tract Morphogenesis Regulation Of Glycoprotein Biosynthetic Process Regulation Of Protein Export From Nucleus Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Apoptotic Process Positive Regulation Of Glucose Metabolic Process
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