PRPF6 and SRSF2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRPF6	SRSF2
Description		pre-mRNA processing factor 6	serine and arginine rich splicing factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Centrosome Cytosol Membrane Nuclear Speck Ciliary Basal Body U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytosol PML Body Nuclear Speck
	Molecular Function	RNA Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Ribonucleoprotein Complex Binding	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Localization RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of DNA-templated Transcription
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Body mass index ( 28552196) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		67 interacting genes: AR ARAF BAG4 BICD2 C1orf35 CD2BP2 CEBPA CEP55 CLK2 CPSF7 CTBP1 CTTN DDX17 DMRTB1 EFTUD2 EHMT2 ESR1 EXOSC7 EXOSC8 FHIT FXR2 HNRNPLL HOOK1 IDH3A KIF24 KRT31 LARP4 LMNA MRPL1 MRPL44 MRPS11 NIN NME1 NR3C1 PCM1 PHF5A PPIE QKI RAF1 RBM22 RBPMS RNF10 RPL36AL RYBP SF3B4 SMARCA2 SNRNP200 SNRNP48 SNRNP70 SNRPA SNRPF SRRM2 SRSF2 SRSF8 SUMO2 SUN2 TFIP11 THOC1 TIMM44 TRAK1 TRMT1L TSNAXIP1 TXNL4B USO1 VIM YWHAB ZRSR2	36 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIRSR CSNK2A1 DMRTB1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC PRPF6 SCAF11 SNRNP70 SREK1 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 USP40 YTHDC1 ZRANB2 ZRSR2
Entrez ID		24148	6427
HPRD ID		10729	02888
Ensembl ID		ENSG00000101161	ENSG00000161547
Uniprot IDs		O94906	Q01130 Q53FN0
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O	2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?		RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex RNA Metabolic Process Nucleic Acid Binding Nuclear Speck Nucleus Nucleic Acid Metabolic Process Macromolecule Metabolic Process MRNA Binding Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Nucleoplasm Regulation Of RNA Splicing U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome Protein Binding Identical Protein Binding U2-type Catalytic Step 2 Spliceosome U5 SnRNP Ribonucleoprotein Complex Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Estrogen Response Element Binding Regulation Of MRNA Processing Microtubule Anchoring At Microtubule Organizing Center Spliceosomal Complex Assembly U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing U1 SnRNP Estrogen Receptor Signaling Pathway Regulation Of Primary Metabolic Process Microtubule Anchoring U2-type Prespliceosome Assembly Protein-RNA Complex Assembly Nuclear Migration Regulation Of Alternative MRNA Splicing, Via Spliceosome U2 SnRNP Nuclear Matrix Steroid Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process U2-type Spliceosomal Complex Steroid Hormone Receptor Signaling Pathway	RNA Splicing MRNA Processing MRNA Metabolic Process Nuclear Speck RNA Processing Nucleic Acid Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Nucleoplasm RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Spliceosomal Complex Nucleic Acid Binding Regulation Of MRNA Processing RNA Binding Macromolecule Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Spliceosomal Complex Assembly Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Aggrephagy Regulation Of RNA Metabolic Process Protein-RNA Complex Assembly Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of Autophagy Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Regulation Of DNA Repair Regulation Of Autophagy Negative Regulation Of Catabolic Process Negative Regulation Of DNA Recombination MRNA Binding Regulation Of DNA Recombination Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Membraneless Organelle Assembly Cellular Response To Glucose Stimulus Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Sequence-specific MRNA Binding Regulation Of Hematopoietic Stem Cell Differentiation Cellular Response To Carbohydrate Stimulus
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