SNRPC and RBM4

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		SNRPC	RBM4
Description		small nuclear ribonucleoprotein polypeptide C	RNA binding motif protein 4
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GO Annotations	Cellular Component	Commitment Complex Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Cajal Body U2-type Prespliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Zinc Ion Binding U1 SnRNA Binding Pre-mRNA 5'-splice Site Binding Protein Homodimerization Activity Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Cyclin Binding MiRNA Binding Pre-mRNA Binding Metal Ion Binding Pre-mRNA Intronic Binding Pre-mRNA Intronic Pyrimidine-rich Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome	Regulation Of Alternative MRNA Splicing, Via Spliceosome Cap-independent Translational Initiation IRES-dependent Translational Initiation Of Linear MRNA RNA Processing MRNA Processing Circadian Rhythm RNA Splicing Regulation Of Gene Expression Negative Regulation Of Translation Cell Differentiation Pancreas Development Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Insulin Secretion Involved In Cellular Response To Glucose Stimulus Enteroendocrine Cell Differentiation Glucose Homeostasis Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Response To Arsenic-containing Substance Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Muscle Cell Differentiation Circadian Regulation Of Translation
Pathways		mRNA Splicing - Major Pathway	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 25961943) Hip circumference adjusted for BMI ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 33830993) Myocardial infarction ( 33532862) Obese vs. thin ( 30677029) Refractive error ( 32231278) Systemic lupus erythematosus ( 24871463)	Bipolar disorder ( 21926972)
Interacting Genes		85 interacting genes: ACTMAP AGGF1 AKAP8L ANKRD10 ARHGAP9 BAG4 BCAS2 BOLL CPSF7 CREM CYSRT1 DAZAP2 DDX42 DMRTB1 ECM1 EWSR1 EXOSC8 EYA2 FAM168A FAM168B FHL3 FOXP1 FUBP1 GIGYF1 GOLGA2 HNRNPDL HNRNPF HNRNPH1 HNRNPH2 HNRNPUL1 HOXA1 HSD17B14 INTS11 JMJD7 KHDRBS3 KLF1 KRT31 KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP22-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 MAGED1 METTL27 MGAT5B MKRN3 NCAPH2 NCKIPSD ODAM PLA2G10 PRDM14 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 QKI RAMAC RBFOX2 RBM11 RBM4 RBPMS RERE RFX6 RNF31 RUNX1 SEC23B SNRNP70 SPAG8 SS18L1 STH TENT5A TLE5 TRIB3 UFSP1 WDR77 WWOX WWP2	97 interacting genes: AQR CCNA1 CDK2 DDX17 DDX5 DHX9 ESS2 HNRNPF HNRNPH2 HNRNPH3 HNRNPK HNRNPM HNRNPUL1 KLHL41 LRP2BP MAPK8IP2 MIR1-1 MIR1-2 MIR106A MIR106B MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15B MIR16-2 MIR17 MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PABPC1 PRPF31 PTBP2 PTEN RBM10 RBM22 RBM23 RBM42 RBM7 RNF10 SF1 SF3B4 SMAD5 SNRPC STEEP1 SURF6 TRIB3 U2AF2
Entrez ID		6631	5936
HPRD ID		04630	03982
Ensembl ID		ENSG00000124562	ENSG00000173933
Uniprot IDs		P09234 Q5TAL4	Q9BWF3
PDB IDs		2VRD 3CW1 4PJO 6ELD 6QX9 7VPX	2DNQ
Enriched GO Terms of Interacting Partners?		Intermediate Filament Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Binding RNA Splicing Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression MRNA Binding Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Nucleus Nucleoplasm Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Cytosol Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Positive Regulation Of MRNA Catabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Regulation Of Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Cell Motility Negative Regulation Of Vasculature Development Regulation Of MRNA Stability Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Cytokine Production Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Developmental Process Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration MRNA Splicing, Via Spliceosome Negative Regulation Of Signal Transduction RNA Splicing, Via Transesterification Reactions Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Cell Motility
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