SNRPC and RERE

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNRPC	RERE
Description		small nuclear ribonucleoprotein polypeptide C	arginine-glutamic acid dipeptide repeats
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GO Annotations	Cellular Component	Commitment Complex Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Cajal Body U2-type Prespliceosome Ribonucleoprotein Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Nuclear Body
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Zinc Ion Binding U1 SnRNA Binding Pre-mRNA 5'-splice Site Binding Protein Homodimerization Activity Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome	Chromatin Remodeling Regulation Of DNA-templated Transcription Cerebellum Development Cerebellar Purkinje Cell Layer Maturation Cerebellar Granule Cell Precursor Proliferation Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Branching Morphogenesis Of A Nerve Dendrite Morphogenesis
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 25961943) Hip circumference adjusted for BMI ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 33830993) Myocardial infarction ( 33532862) Obese vs. thin ( 30677029) Refractive error ( 32231278) Systemic lupus erythematosus ( 24871463)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Asthma ( 34103634 32296059 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Autoimmune thyroid disease ( 32581359) Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Daytime nap ( 33568662) Depression ( 29700475) Diastolic blood pressure ( 27841878) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Feeling miserable ( 29500382) Femoral neck bone mineral density ( 22504420) Fish- and plant-related diet ( 32066663) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 28869591 30598549) Hippocampal volume in normal cognition ( 29274321) Loneliness ( 31518406) Lymphocyte count ( 32888494 27863252) Major depressive disorder ( 27479909) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Optic cup area ( 25631615 28073927) Parkinson's disease ( 32201043) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656 30285260) Smoking initiation ( 30617275 33082346) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 33536424) Systolic blood pressure ( 30578418) Tonsillectomy ( 28928442 27182965) Total body bone mineral density ( 29304378) Total carotid plaque area (excess vs minimal atherosclerosis) ( 32811377) Upper eyelid morphology ( 29921221) Vertical cup-disc ratio ( 25241763 20548946) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494 27863252)
Interacting Genes		85 interacting genes: ACTMAP AGGF1 AKAP8L ANKRD10 ARHGAP9 BAG4 BCAS2 BOLL CPSF7 CREM CYSRT1 DAZAP2 DDX42 DMRTB1 ECM1 EWSR1 EXOSC8 EYA2 FAM168A FAM168B FHL3 FOXP1 FUBP1 GIGYF1 GOLGA2 HNRNPDL HNRNPF HNRNPH1 HNRNPH2 HNRNPUL1 HOXA1 HSD17B14 INTS11 JMJD7 KHDRBS3 KLF1 KRT31 KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP22-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 MAGED1 METTL27 MGAT5B MKRN3 NCAPH2 NCKIPSD ODAM PLA2G10 PRDM14 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 QKI RAMAC RBFOX2 RBM11 RBM4 RBPMS RERE RFX6 RNF31 RUNX1 SEC23B SNRNP70 SPAG8 SS18L1 STH TENT5A TLE5 TRIB3 UFSP1 WDR77 WWOX WWP2	25 interacting genes: ALG13 ATN1 CBFA2T2 CCDC120 ECM1 EFEMP1 EFEMP2 EHMT2 H3C14 KAT6A KRTAP12-4 KRTAP4-12 KRTAP6-2 LZTR1 NR2E1 PLSCR1 PRRC2A PRRC2B PSMA3 RBFOX2 SNRPC TRIM22 TRIP6 VHL ZMYND8
Entrez ID		6631	473
HPRD ID		04630	05566
Ensembl ID		ENSG00000124562	ENSG00000142599
Uniprot IDs		P09234 Q5TAL4	Q9P2R6
PDB IDs		2VRD 3CW1 4PJO 6ELD 6QX9 7VPX	2YQK
Enriched GO Terms of Interacting Partners?		Intermediate Filament Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Binding RNA Splicing Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression MRNA Binding Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Nucleus Nucleoplasm Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Cytosol Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Transcription Corepressor Activity Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Cajal Body Protein Binding Developmental Process Zinc Ion Binding Camera-type Eye Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Extracellular Matrix Structural Constituent Regulation Of Gene Expression Epidermal Growth Factor Receptor Binding Eye Development DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Forebrain Generation Of Neurons Histone H3K56 Methyltransferase Activity Positive Regulation Of Smooth Muscle Cell-matrix Adhesion N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase Activity Endoplasmic Reticulum Tubular Network Maintenance
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