SNRPC and FUBP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNRPC	FUBP1
Description		small nuclear ribonucleoprotein polypeptide C	far upstream element binding protein 1
Image
GO Annotations	Cellular Component	Commitment Complex Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Cajal Body U2-type Prespliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Zinc Ion Binding U1 SnRNA Binding Pre-mRNA 5'-splice Site Binding Protein Homodimerization Activity Metal Ion Binding	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of Gene Expression
Pathways		mRNA Splicing - Major Pathway
Drugs			Irofulven Sacituzumab govitecan
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 25961943) Hip circumference adjusted for BMI ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 33830993) Myocardial infarction ( 33532862) Obese vs. thin ( 30677029) Refractive error ( 32231278) Systemic lupus erythematosus ( 24871463)	A body shape index ( 34021172) Age at first sexual intercourse ( 34211149) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Hip circumference adjusted for BMI ( 34021172) Lung cancer in never smokers ( 28604730) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		85 interacting genes: ACTMAP AGGF1 AKAP8L ANKRD10 ARHGAP9 BAG4 BCAS2 BOLL CPSF7 CREM CYSRT1 DAZAP2 DDX42 DMRTB1 ECM1 EWSR1 EXOSC8 EYA2 FAM168A FAM168B FHL3 FOXP1 FUBP1 GIGYF1 GOLGA2 HNRNPDL HNRNPF HNRNPH1 HNRNPH2 HNRNPUL1 HOXA1 HSD17B14 INTS11 JMJD7 KHDRBS3 KLF1 KRT31 KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP22-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 MAGED1 METTL27 MGAT5B MKRN3 NCAPH2 NCKIPSD ODAM PLA2G10 PRDM14 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 QKI RAMAC RBFOX2 RBM11 RBM4 RBPMS RERE RFX6 RNF31 RUNX1 SEC23B SNRNP70 SPAG8 SS18L1 STH TENT5A TLE5 TRIB3 UFSP1 WDR77 WWOX WWP2	25 interacting genes: AIMP2 ANXA11 CCNH CEBPA CELF1 CHD3 CRMP1 ESR1 GTF2H1 IMMT MAPK1IP1L MYOC PRPF40B PRR13 PUF60 SIRPA SMN1 SMURF2 SNRPA SNRPC TIAL1 TLE1 U2AF2 VIM VPS37C
Entrez ID		6631	8880
HPRD ID		04630	10349
Ensembl ID		ENSG00000124562	ENSG00000162613
Uniprot IDs		P09234 Q5TAL4	A0A384MDX9 A0A994J3Q8 B4DT31 C9JSZ1 Q96AE4
PDB IDs		2VRD 3CW1 4PJO 6ELD 6QX9 7VPX	1J4W 2KXH 4LIJ 6Y24 6Y2C 6Y2D 8P25
Enriched GO Terms of Interacting Partners?		Intermediate Filament Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Binding RNA Splicing Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression MRNA Binding Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Nucleus Nucleoplasm Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Cytosol Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process	RNA Binding RNA Splicing, Via Transesterification Reactions RNA Splicing Nucleoplasm RNA Metabolic Process MRNA Processing U2-type Prespliceosome U1 SnRNP Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition MRNA Metabolic Process Commitment Complex Nucleic Acid Metabolic Process U1 SnRNA Binding Nucleus Nucleobase-containing Compound Metabolic Process Transcription Factor TFIIH Core Complex Nucleic Acid Binding Transcription Factor TFIIH Holo Complex RNA Processing Transcription By RNA Polymerase I Negative Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Regulation Of MRNA Splicing, Via Spliceosome Nuclear Matrix Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Skeletal Muscle Hypertrophy Regulation Of RNA Metabolic Process Protein-containing Complex Assembly Spliceosomal SnRNP Assembly
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