SNRPC and KRTAP22-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNRPC	KRTAP22-1
Description		small nuclear ribonucleoprotein polypeptide C	keratin associated protein 22-1
Image			No pdb structure
GO Annotations	Cellular Component	Commitment Complex Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Cajal Body U2-type Prespliceosome Ribonucleoprotein Complex	Cytosol Intermediate Filament
	Molecular Function	Nucleic Acid Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Zinc Ion Binding U1 SnRNA Binding Pre-mRNA 5'-splice Site Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway	Keratinization
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 25961943) Hip circumference adjusted for BMI ( 34021172) Low density lipoprotein cholesterol levels ( 32154731) Multisite chronic pain ( 33830993) Myocardial infarction ( 33532862) Obese vs. thin ( 30677029) Refractive error ( 32231278) Systemic lupus erythematosus ( 24871463)
Interacting Genes		85 interacting genes: ACTMAP AGGF1 AKAP8L ANKRD10 ARHGAP9 BAG4 BCAS2 BOLL CPSF7 CREM CYSRT1 DAZAP2 DDX42 DMRTB1 ECM1 EWSR1 EXOSC8 EYA2 FAM168A FAM168B FHL3 FOXP1 FUBP1 GIGYF1 GOLGA2 HNRNPDL HNRNPF HNRNPH1 HNRNPH2 HNRNPUL1 HOXA1 HSD17B14 INTS11 JMJD7 KHDRBS3 KLF1 KRT31 KRTAP11-1 KRTAP13-2 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP21-2 KRTAP22-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 MAGED1 METTL27 MGAT5B MKRN3 NCAPH2 NCKIPSD ODAM PLA2G10 PRDM14 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA3 QKI RAMAC RBFOX2 RBM11 RBM4 RBPMS RERE RFX6 RNF31 RUNX1 SEC23B SNRNP70 SPAG8 SS18L1 STH TENT5A TLE5 TRIB3 UFSP1 WDR77 WWOX WWP2	14 interacting genes: ARID5A CAMK2A CHRD CREB5 FOXD2 MEIS2 MGAT5B OTX1 RNF44 SMARCC1 SNRPC VENTX ZIC1 ZNHIT2
Entrez ID		6631	337979
HPRD ID		04630	11216
Ensembl ID		ENSG00000124562	ENSG00000186924
Uniprot IDs		P09234 Q5TAL4	Q3MIV0
PDB IDs		2VRD 3CW1 4PJO 6ELD 6QX9 7VPX
Enriched GO Terms of Interacting Partners?		Intermediate Filament Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Binding MRNA Processing RNA Processing MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Binding RNA Splicing Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression MRNA Binding Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Nucleus Nucleoplasm Identical Protein Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Cytosol Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process	Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Peptidyl-threonine Autophosphorylation DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Diencephalon Morphogenesis Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Inner Ear Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Forebrain Development DNA-binding Transcription Factor Activity Regulation Of Endocannabinoid Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cardiac Muscle Myoblast Proliferation Metencephalon Development
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