SMPD1 and BEX3

Number of citations of the paper that reports this interaction (PubMedID 11238738)
0

Data Source:
HPRD (in vivo)

		SMPD1	BEX3
Description		sphingomyelin phosphodiesterase 1	brain expressed X-linked 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endosome Lipid Droplet Plasma Membrane Endolysosome Lamellar Body Lysosomal Lumen Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Phosphatidylcholine Phospholipase C Activity Metal Ion Binding Acid Sphingomyelin Phosphodiesterase Activity	Signaling Receptor Binding Death Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Metal Ion Binding Molecular Function Inhibitor Activity
	Biological Process	Plasma Membrane Repair Lipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Response To Xenobiotic Stimulus Response To Virus Response To Ionizing Radiation Termination Of Signal Transduction Cholesterol Efflux Response To Type I Interferon Response To Tumor Necrosis Factor Cellular Response To UV Wound Healing Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Endocytosis Glycosphingolipid Catabolic Process Ceramide Biosynthetic Process Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Pyroptotic Inflammatory Response Response To Interleukin-1 Cellular Response To Calcium Ion	Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Ubiquitination
Pathways		Glycosphingolipid catabolism	NADE modulates death signalling
Drugs		Amlodipine Chlorpromazine Desipramine Medical Cannabis
Diseases		Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Malaria ( 31844061) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2	43 interacting genes: AIMP2 BFSP2 CACYBP CBY2 CCDC116 CCDC85B CTNNBL1 DIABLO DSCR9 EMILIN1 ENKD1 FSD2 FTCD GOLGA8EP GOLGA8F ING4 ING5 KRT34 MCCD1 MDFI MIF MNAT1 NECAB2 NGFR NTRK3 PTPN13 S100A1 S100Z SIVA1 SMARCD1 SMPD1 TACC3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TSNAX USHBP1 VTA1 YWHAE ZNF417
Entrez ID		6609	27018
HPRD ID		06353	02291
Ensembl ID		ENSG00000166311	ENSG00000166681
Uniprot IDs		E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0	Q00994
PDB IDs		5I81 5I85 5I8R 5JG8
Enriched GO Terms of Interacting Partners?		Phosphatidylserine Binding Calcium-dependent Protein Binding Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Calcium-dependent Phospholipid Binding Epithelial Cell Differentiation Vesicle Membrane Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Regulation Of High-density Lipoprotein Particle Assembly Regulation Of Cytokine-mediated Signaling Pathway Fatty Acid Amide Hydrolase Activity Regulation Of Lipid Biosynthetic Process N-acylsphingosine Amidohydrolase Activity Apolipoprotein A-I Receptor Binding Negative Regulation Of Pinocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Type II Interferon-mediated Signaling Pathway Nucleus Chromaffin Granule Membrane Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Cell Differentiation Negative Regulation Of Biosynthetic Process Phospholipase Inhibitor Activity Negative Regulation Of Gene Expression Response To Phorbol 13-acetate 12-myristate Sphingoid Biosynthetic Process Sphingosine Biosynthetic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Digestive System Process Regulation Of Type II Interferon-mediated Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Regulation Of Response To Type II Interferon Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Regulation Of Lipid Metabolic Process Zymogen Granule Membrane Nuclear Retinoid X Receptor Binding Death Receptor Binding Sphingosine Metabolic Process Ceramide Catabolic Process Regulation Of Triglyceride Biosynthetic Process Protein Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of DNA-templated Transcription	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Programmed Cell Death CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction A2A Adenosine Receptor Binding DNA Replication-dependent Chromatin Disassembly Regulation Of MAPK Cascade Neurotrophin Binding Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Process Identical Protein Binding Cell Death Programmed Cell Death Regulation Of DNA-binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Macrophage Migration S100 Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Cytoplasm Zinc Ion Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of Cell Communication Regulation Of Signaling Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Immune Response Histone H3K4me3 Reader Activity Regulation Of Macromolecule Metabolic Process
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