SMPD1

Description		sphingomyelin phosphodiesterase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endosome Lipid Droplet Plasma Membrane Endolysosome Lamellar Body Lysosomal Lumen Extracellular Exosome
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Phosphatidylcholine Phospholipase C Activity Metal Ion Binding Acid Sphingomyelin Phosphodiesterase Activity
	Biological Process	Plasma Membrane Repair Lipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Response To Xenobiotic Stimulus Response To Virus Response To Ionizing Radiation Termination Of Signal Transduction Cholesterol Efflux Response To Type I Interferon Response To Tumor Necrosis Factor Cellular Response To UV Wound Healing Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Endocytosis Glycosphingolipid Catabolic Process Ceramide Biosynthetic Process Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Pyroptotic Inflammatory Response Response To Interleukin-1 Cellular Response To Calcium Ion
Pathways		Glycosphingolipid catabolism
Drugs		Amlodipine Chlorpromazine Desipramine Medical Cannabis
Diseases		Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Malaria ( 31844061) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2
Entrez ID		6609
HPRD ID		06353
Ensembl ID		ENSG00000166311
Uniprot IDs		E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0
PDB IDs		5I81 5I85 5I8R 5JG8
Enriched GO Terms of Interacting Partners?		Phosphatidylserine Binding Calcium-dependent Protein Binding Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Calcium-dependent Phospholipid Binding Epithelial Cell Differentiation Vesicle Membrane Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Regulation Of High-density Lipoprotein Particle Assembly Regulation Of Cytokine-mediated Signaling Pathway Fatty Acid Amide Hydrolase Activity Regulation Of Lipid Biosynthetic Process N-acylsphingosine Amidohydrolase Activity Apolipoprotein A-I Receptor Binding Negative Regulation Of Pinocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Type II Interferon-mediated Signaling Pathway Nucleus Chromaffin Granule Membrane Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Cell Differentiation Negative Regulation Of Biosynthetic Process Phospholipase Inhibitor Activity Negative Regulation Of Gene Expression Response To Phorbol 13-acetate 12-myristate Sphingoid Biosynthetic Process Sphingosine Biosynthetic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Digestive System Process Regulation Of Type II Interferon-mediated Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Regulation Of Response To Type II Interferon Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Regulation Of Lipid Metabolic Process Zymogen Granule Membrane Nuclear Retinoid X Receptor Binding Death Receptor Binding Sphingosine Metabolic Process Ceramide Catabolic Process Regulation Of Triglyceride Biosynthetic Process Protein Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of DNA-templated Transcription
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