SMPD1

Gene Name		sphingomyelin phosphodiesterase 1, acid lysosomal
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Sphingolipid Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Ceramide Biosynthetic Process
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism
Drugs		Desipramine
Diseases
GWAS
Protein-protein Interactions		6 interactors: ANXA4 ANXA7 ASAH1 DUSP23 NGFRAP1 NR1H2
Entrez ID		6609
HPRD ID		06353
Ensembl ID		ENSG00000166311
Uniprot IDs		G3XAB5 P17405 Q59EN6
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Interleukin-8 Secretion Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Response To Organic Substance Negative Regulation Of Cholesterol Storage Positive Regulation Of Digestive System Process Cellular Water Homeostasis Negative Regulation Of Interleukin-8 Production Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Interleukin-8 Secretion Regulation Of Cholesterol Homeostasis Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Protein Secretion Negative Regulation Of Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway Epithelial Cell Differentiation Positive Regulation Of Lipid Storage Cell Volume Homeostasis Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Regulation Of Cholesterol Transport Negative Regulation Of Cytokine Secretion Response To Salt Stress Regulation Of Protein Transport Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway
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