SMPD1 and ANXA4

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SMPD1	ANXA4
Gene Name		sphingomyelin phosphodiesterase 1, acid lysosomal	annexin A4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Cell Surface Vesicle Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds	Phospholipase Inhibitor Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding
	Biological Process	Sphingolipid Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Ceramide Biosynthetic Process	Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Interleukin-8 Secretion
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism
Drugs		Desipramine
Diseases
GWAS			Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		6 interactors: ANXA4 ANXA7 ASAH1 DUSP23 NGFRAP1 NR1H2	7 interactors: GP2 NMT2 PADI4 POT1 SMPD1 TINF2 UCHL5
Entrez ID		6609	307
HPRD ID		06353	00112
Ensembl ID		ENSG00000166311	ENSG00000196975
Uniprot IDs		G3XAB5 P17405 Q59EN6	P09525 Q6LES2 Q6P452
PDB IDs			2ZOC
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Interleukin-8 Secretion Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Response To Organic Substance Negative Regulation Of Cholesterol Storage Positive Regulation Of Digestive System Process Cellular Water Homeostasis Negative Regulation Of Interleukin-8 Production Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Interleukin-8 Secretion Regulation Of Cholesterol Homeostasis Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Protein Secretion Negative Regulation Of Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway Epithelial Cell Differentiation Positive Regulation Of Lipid Storage Cell Volume Homeostasis Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Regulation Of Cholesterol Transport Negative Regulation Of Cytokine Secretion Response To Salt Stress Regulation Of Protein Transport Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway	Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Antigen Transcytosis By M Cells In Mucosal-associated Lymphoid Tissue Negative Regulation Of DNA Metabolic Process Regulation Of Protein ADP-ribosylation N-terminal Peptidyl-glycine N-myristoylation Histone Citrullination Histone H3-R26 Citrullination Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Telomere Formation Via Telomerase Negative Regulation Of Protein Glycosylation Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Protein Citrullination Regulation Of Chromosome Organization Negative Regulation Of Protein Metabolic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Helicase Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Sphingomyelin Catabolic Process Citrulline Biosynthetic Process Chromosome Organization DNA Metabolic Process N-terminal Protein Myristoylation DNA Conformation Change Regulation Of Protein Glycosylation Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Protein Myristoylation Citrulline Metabolic Process Viral Protein Processing Negative Regulation Of Transferase Activity Transcytosis Negative Regulation Of Glycoprotein Metabolic Process Sphingomyelin Metabolic Process Regulation Of Telomerase Activity
Tagcloud ?			anxa2 calbindin1 cascades categorized cofilin1 cytoskeleton ddah2 differentially dj e40 e70 e93 electrophoresis elucidated embryonic expressional fetoprotein functionally grp75 kidney kidneys pig proteomic representative serves sod2 subjected tandem vil1
Tagcloud (Difference) ?			anxa2 calbindin1 cascades categorized cofilin1 cytoskeleton ddah2 differentially dj e40 e70 e93 electrophoresis elucidated embryonic expressional fetoprotein functionally grp75 kidney kidneys pig proteomic representative serves sod2 subjected tandem vil1
Tagcloud (Intersection) ?