SMPD1 and NR1H2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SMPD1	NR1H2
Gene Name		sphingomyelin phosphodiesterase 1, acid lysosomal	nuclear receptor subfamily 1, group H, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific Transcription Regulatory Region DNA Binding RNA Polymerase II Transcription Factor Recruiting Transcription Factor Activity DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Apolipoprotein A-I Receptor Binding Retinoid X Receptor Binding ATPase Binding
	Biological Process	Sphingolipid Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Ceramide Biosynthetic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of Secretion Of Lysosomal Enzymes Regulation Of Cholesterol Homeostasis
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs		Desipramine	(3-{3-[[2-Chloro-3-(Trifluoromethyl)Benzyl](2,2-Diphenylethyl)Amino]Propoxy}Phenyl)Acetic Acid Benzenesulfonyl N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE 1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ANXA4 ANXA7 ASAH1 DUSP23 NGFRAP1 NR1H2	46 interactors: BAG6 C14orf1 CDKN1A CHD3 COL4A5 CSAD DUSP12 FAF1 FOXO3 HDAC4 HMGXB4 ING3 KDM1A LAMC3 MDFI MED1 MPP1 NCOA3 NCOA6 NCOR1 NCOR2 NPY NR0B2 NRIP1 PCDH17 PRKCA RARA RMI1 ROBO2 RXRA RXRB RXRG SCG5 SIRT1 SMPD1 SORBS2 SPRY2 SRC SUV39H1 TMEM161A UBE2D1 UBE2I VDR VIM YY1 ZXDC
Entrez ID		6609	7376
HPRD ID		06353	02660
Ensembl ID		ENSG00000166311	ENSG00000131408
Uniprot IDs		G3XAB5 P17405 Q59EN6	B4DNM6 F1D8P7 M0R2F9 P55055
PDB IDs			1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Interleukin-8 Secretion Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Response To Organic Substance Negative Regulation Of Cholesterol Storage Positive Regulation Of Digestive System Process Cellular Water Homeostasis Negative Regulation Of Interleukin-8 Production Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Interleukin-8 Secretion Regulation Of Cholesterol Homeostasis Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Protein Secretion Negative Regulation Of Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway Epithelial Cell Differentiation Positive Regulation Of Lipid Storage Cell Volume Homeostasis Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Regulation Of Cholesterol Transport Negative Regulation Of Cytokine Secretion Response To Salt Stress Regulation Of Protein Transport Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway	Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Organic Substance Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Reproductive Structure Development Reproductive System Development System Development Positive Regulation Of Gene Expression Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Hormone Multicellular Organismal Development Cell Differentiation Single Organism Reproductive Process Anatomical Structure Development Developmental Process Involved In Reproduction Developmental Process Reproductive Process Cellular Response To Steroid Hormone Stimulus Signal Transduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cellular Response To Organic Substance Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Chromatin Organization Response To Stimulus Hormone-mediated Signaling Pathway Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Signaling
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