SMPD1 and ASAH1

Number of citations of the paper that reports this interaction (PMID 12815059)
20

Data Source:
HPRD (in vitro)

		SMPD1	ASAH1
Gene Name		sphingomyelin phosphodiesterase 1, acid lysosomal	N-acylsphingosine amidohydrolase (acid ceramidase) 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Vesicular Exosome	Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds	Catalytic Activity Ceramidase Activity
	Biological Process	Sphingolipid Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Ceramide Biosynthetic Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Glycosphingolipid Metabolic Process Response To Organic Substance Lung Development Small Molecule Metabolic Process
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism	Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism
Drugs		Desipramine
Diseases
GWAS			Obesity ( 21552555)
Protein-Protein Interactions		6 interactors: ANXA4 ANXA7 ASAH1 DUSP23 NGFRAP1 NR1H2	5 interactors: CAMK1D SETDB1 SMPD1 SRPK1 TSC22D1
Entrez ID		6609	427
HPRD ID		06353	01969
Ensembl ID		ENSG00000166311	ENSG00000104763
Uniprot IDs		G3XAB5 P17405 Q59EN6	A8K0B6 E7EMM4 Q13510 Q53H01
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Interleukin-8 Secretion Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Response To Organic Substance Negative Regulation Of Cholesterol Storage Positive Regulation Of Digestive System Process Cellular Water Homeostasis Negative Regulation Of Interleukin-8 Production Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Interleukin-8 Secretion Regulation Of Cholesterol Homeostasis Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Protein Secretion Negative Regulation Of Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway Epithelial Cell Differentiation Positive Regulation Of Lipid Storage Cell Volume Homeostasis Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Regulation Of Cholesterol Transport Negative Regulation Of Cytokine Secretion Response To Salt Stress Regulation Of Protein Transport Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway	Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Sphingomyelin Catabolic Process Positive Regulation Of Respiratory Burst Sperm Chromatin Condensation Histone H3-K9 Trimethylation Regulation Of Apoptotic Process Regulation Of Respiratory Burst Regulation Of Cell Death Sphingomyelin Metabolic Process Regulation Of Metabolic Process Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Protein Dephosphorylation Histone H3-K9 Methylation Inner Cell Mass Cell Proliferation Positive Regulation Of Viral Genome Replication Positive Regulation Of Neutrophil Chemotaxis Regulation Of RNA Metabolic Process Peptidyl-lysine Trimethylation Positive Regulation Of Granulocyte Chemotaxis Phospholipid Catabolic Process Blastocyst Growth Sphingolipid Catabolic Process Spermatid Nucleus Differentiation Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Membrane Lipid Catabolic Process
Tagcloud ?			adjuvant apoptotic best breast cancers ceramidase ceramide converting dcis even generally good improved invasive luminal mainly metabolism moreover overexpressed phenotype pre pro prognosis recurrences sphingolipid sphingosine subtype subtypes valuable
Tagcloud (Difference) ?			adjuvant apoptotic best breast cancers ceramidase ceramide converting dcis even generally good improved invasive luminal mainly metabolism moreover overexpressed phenotype pre pro prognosis recurrences sphingolipid sphingosine subtype subtypes valuable
Tagcloud (Intersection) ?