HSF4 and PIH1D2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSF4	PIH1D2
Description		heat shock transcription factor 4	PIH1 domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Speck	Cytoplasm R2TP Complex Protein Folding Chaperone Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Small GTPase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Lens Fiber Cell Differentiation	Box C/D SnoRNP Assembly RRNA Processing Protein Stabilization
Pathways
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		43 interacting genes: ACTMAP AKAP8L ALKBH4 C10orf55 CDK2AP2 DAXX DUSP26 FAM168B FAM200C FOXH1 FOXI1 GFOD1 HGS INTS11 KRT31 KRT37 KRT38 KRT40 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP6-2 MAPK1 MAPK14 MAPK3 MAPK8 MKRN3 NHLRC4 NUDT21 NUP62 OIP5 PIH1D2 PITX1 PLA2G10 PPFIBP2 SESTD1 SLC27A5 SMARCA4 SOX10 TPM3 UFSP1 YTHDF1 ZMYND12	69 interacting genes: ANKRD11 BAG3 BANP CBLL2 CBX8 CCNL2 CDC23 CDCA8 CDKL3 CFAP206 COMMD3 CT55 CTAG1A CTAG1B DES DPH3 DSCAM EIF4A2 EXOSC5 FRS3 GFAP GMCL1 GPRASP2 HES7 HSF4 IGF2BP3 IQUB ITGB3BP KRTAP12-2 KRTAP12-4 LAP3 LMNB1 MCCD1 MDFI MED20 MISP MRFAP1L1 MVP NFIL3 NHSL2 NOTO NTAQ1 NXF1 PBX4 PLEKHJ1 POLR1C PRDM6 PRMT3 RALA REL RSPO4 SDCBP SERTAD1 SLPI SPRED1 SSX3 SUOX TAF6 TASOR2 TBATA TCEA2 TNNI1 TTC23 ZBTB1 ZMAT5 ZNF185 ZNF417 ZNF438 ZNF688
Entrez ID		3299	120379
HPRD ID		03896	14021
Ensembl ID		ENSG00000102878	ENSG00000150773
Uniprot IDs		Q9ULV5	Q8WWB5
PDB IDs		6J6V 6J6W
Enriched GO Terms of Interacting Partners?		Intermediate Filament MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Interleukin-34-mediated Signaling Pathway Positive Regulation Of Cyclase Activity Nuclear Androgen Receptor Binding Intermediate Filament Organization Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Anatomical Structure Morphogenesis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Lipopolysaccharide-mediated Signaling Pathway Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Morphogenesis Of An Epithelium Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Senescence Tissue Morphogenesis Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Glial Cell Development Negative Regulation Of Cholesterol Efflux Regulation Of Gene Expression P53 Binding Regulation Of Golgi Organization Pseudopodium Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Negative Regulation Of Cholesterol Transport	Protein Binding Nucleus
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