HSF4 and DUSP26

Number of citations of the paper that reports this interaction (PubMedID 16581800)
52

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		HSF4	DUSP26
Description		heat shock transcription factor 4	dual specificity phosphatase 26
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	P53 Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Phosphatase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Lens Fiber Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Negative Regulation Of ERK1 And ERK2 Cascade
Pathways
Drugs
Diseases
GWAS			Body mass index ( 25673413 28892062) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Metabolite levels ( 23823483) Morning person ( 30696823) Reading disability ( 32108986) Self-reported risk-taking behaviour ( 30271922)
Interacting Genes		43 interacting genes: ACTMAP AKAP8L ALKBH4 C10orf55 CDK2AP2 DAXX DUSP26 FAM168B FAM200C FOXH1 FOXI1 GFOD1 HGS INTS11 KRT31 KRT37 KRT38 KRT40 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP6-2 MAPK1 MAPK14 MAPK3 MAPK8 MKRN3 NHLRC4 NUDT21 NUP62 OIP5 PIH1D2 PITX1 PLA2G10 PPFIBP2 SESTD1 SLC27A5 SMARCA4 SOX10 TPM3 UFSP1 YTHDF1 ZMYND12	11 interacting genes: CALCOCO2 CARD10 EPHA2 EPHA7 GOLGA6L9 GRIPAP1 HSF4 IGF1R KRT27 PTK7 RET
Entrez ID		3299	78986
HPRD ID		03896	14421
Ensembl ID		ENSG00000102878	ENSG00000133878
Uniprot IDs		Q9ULV5	Q9BV47
PDB IDs		6J6V 6J6W	2E0T 4B04 4HRF 5GTJ
Enriched GO Terms of Interacting Partners?		Intermediate Filament MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Interleukin-34-mediated Signaling Pathway Positive Regulation Of Cyclase Activity Nuclear Androgen Receptor Binding Intermediate Filament Organization Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Anatomical Structure Morphogenesis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Lipopolysaccharide-mediated Signaling Pathway Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Morphogenesis Of An Epithelium Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Senescence Tissue Morphogenesis Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Glial Cell Development Negative Regulation Of Cholesterol Efflux Regulation Of Gene Expression P53 Binding Regulation Of Golgi Organization Pseudopodium Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Negative Regulation Of Cholesterol Transport	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Tissue Morphogenesis Protein Kinase Activity Axon Guidance Receptor Activity Ephrin Receptor Activity Morphogenesis Of An Epithelium Epithelial Cell Differentiation Axon Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Positive Regulation Of Protein-containing Complex Disassembly Neuron Projection Guidance Axon Guidance Growth Factor Binding Positive Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Notochord Cell Development Kinase Activity Ephrin Receptor Signaling Pathway Regulation Of MAPK Cascade Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Projection Organization Extrinsic Component Of Postsynaptic Early Endosome Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Retinoic Acid ATP Binding Anatomical Structure Morphogenesis Axial Mesoderm Formation Neuronal Cell Body Posterior Midgut Development Negative Regulation Of Receptor Clustering Regulation Of Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Negative Regulation Of Lymphangiogenesis Notochord Formation Plasma Membrane Bounded Cell Projection Organization Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Insulin Receptor Activity Response To Retinoic Acid Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Regulation Of Protein Localization To Plasma Membrane Regulation Of Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Insulin Receptor Complex
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