HSF4 and SESTD1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		HSF4	SESTD1
Description		heat shock transcription factor 4	SEC14 and spectrin domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Speck	Calcium Channel Complex Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Phosphatidylserine Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylcholine Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Lens Fiber Cell Differentiation	Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways
Drugs
Diseases
GWAS			Late-onset Alzheimer's disease ( 27770636) Objective response to lithium treatment ( 26503763) Optic disc size ( 31809533) Presence of antiphospholipid antibodies ( 23509613) Refractive error ( 32231278) Serum uric acid levels ( 29559957)
Interacting Genes		43 interacting genes: ACTMAP AKAP8L ALKBH4 C10orf55 CDK2AP2 DAXX DUSP26 FAM168B FAM200C FOXH1 FOXI1 GFOD1 HGS INTS11 KRT31 KRT37 KRT38 KRT40 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP6-2 MAPK1 MAPK14 MAPK3 MAPK8 MKRN3 NHLRC4 NUDT21 NUP62 OIP5 PIH1D2 PITX1 PLA2G10 PPFIBP2 SESTD1 SLC27A5 SMARCA4 SOX10 TPM3 UFSP1 YTHDF1 ZMYND12	10 interacting genes: CBX8 GPS2 HSF4 IQCB1 NRIP1 RABGEF1 STMN1 STMN2 TEAD4 ZNF830
Entrez ID		3299	91404
HPRD ID		03896	11549
Ensembl ID		ENSG00000102878	ENSG00000187231
Uniprot IDs		Q9ULV5	B3KTX3 Q86VW0
PDB IDs		6J6V 6J6W
Enriched GO Terms of Interacting Partners?		Intermediate Filament MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Interleukin-34-mediated Signaling Pathway Positive Regulation Of Cyclase Activity Nuclear Androgen Receptor Binding Intermediate Filament Organization Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Anatomical Structure Morphogenesis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Lipopolysaccharide-mediated Signaling Pathway Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Morphogenesis Of An Epithelium Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Senescence Tissue Morphogenesis Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Glial Cell Development Negative Regulation Of Cholesterol Efflux Regulation Of Gene Expression P53 Binding Regulation Of Golgi Organization Pseudopodium Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Negative Regulation Of Cholesterol Transport	Negative Regulation Of Microtubule Polymerization Microtubule Depolymerization Microtubule Polymerization Or Depolymerization Protein Depolymerization Ovulation Cycle Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Tubulin Binding Negative Regulation Of Small GTPase Mediated Signal Transduction Trophectodermal Cell Fate Commitment Ovarian Follicle Rupture Regulation Of Microtubule Polymerization BBSome Binding Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Cytokine Production Preantral Ovarian Follicle Growth Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Transcription By RNA Polymerase II Nuclear Speck Regulation Of Microtubule Polymerization Or Depolymerization Kit Signaling Pathway Intracellular Signal Transduction Transcription Coregulator Activity Chromatin Maintenance Of Animal Organ Identity Negative Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Microtubule Depolymerization
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