HSF4 and STOML2

Data Source: HiPPIP (Novel)

		HSF4	STOML2
Name		heat shock transcription factor 4	stomatin like 2
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nuclear Speck	Immunological Synapse Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Membrane Raft
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Lipid Binding T Cell Receptor Binding GTPase Binding Cardiolipin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Lens Fiber Cell Differentiation	Intracellular Calcium Ion Homeostasis Mitochondrion Organization Lipid Localization Positive Regulation Of Interleukin-2 Production Mitochondrial Protein Processing CD4-positive, Alpha-beta T Cell Activation Proton Motive Force-driven Mitochondrial ATP Synthesis T Cell Receptor Signaling Pathway Protein Complex Oligomerization Stress-induced Mitochondrial Fusion
Pathways		None	Processing of SMDT1 Cellular response to mitochondrial stress
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		3 novel interactors: BBS2 CNOT1 STOML2	10 novel interactors: ACOT11 CDH1 HSF4 LNX1 MCC PEX7 RFXANK RNF38 RPS7 TAL1
Interacting Genes		43 interacting genes: ACTMAP AKAP8L ALKBH4 C10orf55 CDK2AP2 DAXX DUSP26 FAM168B FAM200C FOXH1 FOXI1 GFOD1 HGS INTS11 KRT31 KRT37 KRT38 KRT40 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP6-2 MAPK1 MAPK14 MAPK3 MAPK8 MKRN3 NHLRC4 NUDT21 NUP62 OIP5 PIH1D2 PITX1 PLA2G10 PPFIBP2 SESTD1 SLC27A5 SMARCA4 SOX10 TPM3 UFSP1 YTHDF1 ZMYND12	5 interacting genes: APP GLP1R OGT RABAC1 SUMO4
Entrez ID		3299	30968
HPRD ID		03896	16310
Ensembl ID		ENSG00000102878	ENSG00000165283
Uniprot IDs		Q9ULV5	A0A087WYB4 Q9UJZ1
PDB IDs		6J6V 6J6W	Not available
GO Terms Enriched among Interactors		Intermediate Filament MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Keratin Filament Protein Binding Structural Constituent Of Skin Epidermis Interleukin-34-mediated Signaling Pathway Positive Regulation Of Cyclase Activity Nuclear Androgen Receptor Binding Intermediate Filament Organization Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Anatomical Structure Morphogenesis Intermediate Filament Cytoskeleton Organization Structural Molecule Activity Intermediate Filament-based Process Lipopolysaccharide-mediated Signaling Pathway Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Morphogenesis Of An Epithelium Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation MAPK Cascade Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Senescence Tissue Morphogenesis Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Glial Cell Development Negative Regulation Of Cholesterol Efflux Regulation Of Gene Expression P53 Binding Regulation Of Golgi Organization Pseudopodium Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Macrophage Chemotaxis Animal Organ Formation Negative Regulation Of Cholesterol Transport	None