CLDN2 and EMP3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN2	EMP3
Description		claudin 2	epithelial membrane protein 3 (MAM blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Tight Junction Anchoring Junction	Plasma Membrane Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Paracellular Tight Junction Channel Activity	Protein Binding
	Biological Process	Innate Immune Response In Mucosa Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly Cell-cell Adhesion Regulation Of Bile Acid Secretion Paracellular Transport Regulation Of Intestinal D-glucose Absorption Regulation Of Intestinal Lipid Absorption	Apoptotic Process Bleb Assembly
Pathways		Tight junction interactions
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)
Interacting Genes		29 interacting genes: ADAM33 BTN3A2 CLEC2D CSGALNACT2 CXCL9 CYSRT1 EMP3 FAM209A GRM2 IGFBP5 IL27RA KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP4-12 LAT LNX1 LPAR3 MTDH NOTCH2NLA PIAS2 PLP1 TEX264 TJP1 TJP2 TMEM218 UBE2I WNK4	43 interacting genes: AQP6 CD79A CLDN2 CLDN7 CREB3L1 CREM EDA ELOVL7 ERGIC3 FAM210B FNDC9 GJA5 GJB1 GPA33 GPR61 IFNGR2 IL3RA KIR3DL3 KLRC1 LDLRAD1 LEUTX LHFPL5 LRRC4C LYVE1 MR1 MS4A3 MUC1 OPRM1 P2RX7 PLEKHB2 RMDN3 SAR1A SECTM1 SIGLECL1 SLAMF8 SLC30A2 SLC35H1 SMIM3 SPACA1 TM4SF18 TMX2 TSPAN12 VSIG1
Entrez ID		9075	2014
HPRD ID		06471	18514
Ensembl ID		ENSG00000165376	ENSG00000142227
Uniprot IDs		P57739	P54852
PDB IDs		4YYX
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Positive Regulation Of Blood-brain Barrier Permeability Bicellular Tight Junction Regulation Of Blood-brain Barrier Permeability Bleb Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability	Membrane Protein Binding Plasma Membrane Gap Junction Assembly Regulation Of T Cell Mediated Immunity Regulation Of T Cell Mediated Cytotoxicity Cell-cell Junction Assembly
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