CLDN2 and GRM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN2	GRM2
Description		claudin 2	glutamate metabotropic receptor 2
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Tight Junction Anchoring Junction	Plasma Membrane Membrane Axon Dendrite Presynaptic Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane Astrocyte Projection Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Paracellular Tight Junction Channel Activity	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Protein Binding Glutamate Receptor Activity Scaffold Protein Binding
	Biological Process	Innate Immune Response In Mucosa Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly Cell-cell Adhesion Regulation Of Bile Acid Secretion Paracellular Transport Regulation Of Intestinal D-glucose Absorption Regulation Of Intestinal Lipid Absorption	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Gene Expression Glutamate Secretion Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Cellular Response To Stress Behavioral Response To Nicotine Response To Cocaine Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Depression Intracellular Glutamate Homeostasis Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Response To Drug
Pathways		Tight junction interactions	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs			LY2140023
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)
Interacting Genes		29 interacting genes: ADAM33 BTN3A2 CLEC2D CSGALNACT2 CXCL9 CYSRT1 EMP3 FAM209A GRM2 IGFBP5 IL27RA KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP4-12 LAT LNX1 LPAR3 MTDH NOTCH2NLA PIAS2 PLP1 TEX264 TJP1 TJP2 TMEM218 UBE2I WNK4	31 interacting genes: ACBD5 ACE2 AQP6 BIK CCDC107 CLDN2 CLDN9 CPLX4 CYB5R3 GNA15 GNAQ GRIP1 LMNA MGST3 MMGT1 NAALADL2 PDZK1IP1 RGS12 SAR1A SDCBP SLC30A8 SLC38A1 SLC71A2 STOM TAMALIN TFRC TMEM130 TMEM237 TMEM248 TSPAN18 UBQLN1
Entrez ID		9075	2912
HPRD ID		06471	04977
Ensembl ID		ENSG00000165376	ENSG00000164082
Uniprot IDs		P57739	H7BXL3 Q14416
PDB IDs		4YYX	4XAQ 4XAS 5CNI 5CNJ 5KZN 5KZQ 7E9G 7EPA 7EPB 7EPD 7MTQ 7MTR 7MTS 8JCU 8JCV 8JCW 8JCX 8JCY 8JCZ 8JD0 8JD1 8JD2 8JD3 8JD4 8JD5 8WG9 8WGB 8WGC 8WGD
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Positive Regulation Of Blood-brain Barrier Permeability Bicellular Tight Junction Regulation Of Blood-brain Barrier Permeability Bleb Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability	Membrane Plasma Membrane
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