CLDN2 and IL27RA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN2	IL27RA
Description		claudin 2	interleukin 27 receptor subunit alpha
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Tight Junction Anchoring Junction	Plasma Membrane Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Paracellular Tight Junction Channel Activity	Transmembrane Signaling Receptor Activity Protein Binding Interleukin-27 Receptor Activity
	Biological Process	Innate Immune Response In Mucosa Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly Cell-cell Adhesion Regulation Of Bile Acid Secretion Paracellular Transport Regulation Of Intestinal D-glucose Absorption Regulation Of Intestinal Lipid Absorption	Negative Regulation Of Cellular Extravasation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Type II Interferon Production Negative Regulation Of Neuron Apoptotic Process Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation
Pathways		Tight junction interactions	Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	Blood protein levels ( 30072576) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		29 interacting genes: ADAM33 BTN3A2 CLEC2D CSGALNACT2 CXCL9 CYSRT1 EMP3 FAM209A GRM2 IGFBP5 IL27RA KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP4-12 LAT LNX1 LPAR3 MTDH NOTCH2NLA PIAS2 PLP1 TEX264 TJP1 TJP2 TMEM218 UBE2I WNK4	11 interacting genes: CLDN2 DEFB121 DERL3 EBI3 GALNT15 IL27 MAPK8 SLC41A2 SLC61A1 STAT1 YIPF6
Entrez ID		9075	9466
HPRD ID		06471	09247
Ensembl ID		ENSG00000165376	ENSG00000104998
Uniprot IDs		P57739	Q6UWB1
PDB IDs		4YYX	7T5M 7U7N 8D85
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Positive Regulation Of Blood-brain Barrier Permeability Bicellular Tight Junction Regulation Of Blood-brain Barrier Permeability Bleb Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability	Interleukin-27 Receptor Binding JUN Phosphorylation Response To Stress Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus By Host Response To Metformin Cytokine Activity Molybdate Ion Transmembrane Transporter Activity Molybdate Ion Transport Response To External Biotic Stimulus Energy Homeostasis Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Defense Response To Virus Negative Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Intestinal D-glucose Absorption Positive Regulation Of Type II Interferon Production Nickel Cation Transport
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