CLDN2 and BTN3A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN2	BTN3A2
Description		claudin 2	butyrophilin subfamily 3 member A2
Image
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Tight Junction Anchoring Junction	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Paracellular Tight Junction Channel Activity	Signaling Receptor Binding Protein Binding
	Biological Process	Innate Immune Response In Mucosa Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly Cell-cell Adhesion Regulation Of Bile Acid Secretion Paracellular Transport Regulation Of Intestinal D-glucose Absorption Regulation Of Intestinal Lipid Absorption	Regulation Of Cytokine Production Adaptive Immune Response Immune System Process T Cell Mediated Immunity Positive Regulation Of Type II Interferon Production T Cell Receptor Signaling Pathway
Pathways		Tight junction interactions	Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Epstein-Barr virus VCA p18 antibody levels ( 33204752) Fish- and plant-related diet ( 32066663) General cognitive ability ( 29844566) Hip circumference ( 31453325) Hip circumference adjusted for BMI ( 34021172) Hip circumference variance ( 31453325) Liver iron content ( 34128465) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Schizophrenia ( 19571809) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		29 interacting genes: ADAM33 BTN3A2 CLEC2D CSGALNACT2 CXCL9 CYSRT1 EMP3 FAM209A GRM2 IGFBP5 IL27RA KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP4-12 LAT LNX1 LPAR3 MTDH NOTCH2NLA PIAS2 PLP1 TEX264 TJP1 TJP2 TMEM218 UBE2I WNK4	2 interacting genes: ACE2 CLDN2
Entrez ID		9075	11118
HPRD ID		06471	12547
Ensembl ID		ENSG00000165376	ENSG00000186470
Uniprot IDs		P57739	A8K4B5 P78410
PDB IDs		4YYX	4F8Q
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Positive Regulation Of Blood-brain Barrier Permeability Bicellular Tight Junction Regulation Of Blood-brain Barrier Permeability Bleb Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability	Regulation Of Intestinal D-glucose Absorption Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Entry Receptor-mediated Virion Attachment To Host Cell Regulation Of Bile Acid Secretion Viral Translation Viral Life Cycle Tryptophan Transport Paracellular Tight Junction Channel Activity Positive Regulation Of Gap Junction Assembly Paracellular Transport Receptor-mediated Virion Attachment To Host Cell Regulation Of Intestinal Lipid Absorption Regulation Of System Process Aromatic Amino Acid Transport Transporter Activator Activity Positive Regulation Of Cardiac Muscle Contraction Adhesion Of Symbiont To Host Cell Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Regulation Of Gap Junction Assembly Virion Attachment To Host Cell Drinking Behavior Regulation Of Intestinal Absorption Adhesion Of Symbiont To Host Positive Regulation Of Striated Muscle Contraction Endocytosis Involved In Viral Entry Into Host Cell Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Innate Immune Response In Mucosa Positive Regulation Of Amino Acid Transport Metallocarboxypeptidase Activity Regulation Of Cardiac Conduction Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Mucosal Immune Response Carboxypeptidase Activity Maternal Process Involved In Female Pregnancy Organ Or Tissue Specific Immune Response Tight Junction Peptide Hormone Processing Positive Regulation Of Heart Contraction Signaling Receptor Ligand Precursor Processing Regulation Of Systemic Arterial Blood Pressure Bicellular Tight Junction Assembly Positive Regulation Of Muscle Contraction Tight Junction Assembly Brush Border Membrane Ceramide Biosynthetic Process Tight Junction Organization
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