CLDN2 and ADAM33

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CLDN2	ADAM33
Description		claudin 2	ADAM metallopeptidase domain 33
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Tight Junction Anchoring Junction	Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding Paracellular Tight Junction Channel Activity	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Innate Immune Response In Mucosa Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly Cell-cell Adhesion Regulation Of Bile Acid Secretion Paracellular Transport Regulation Of Intestinal D-glucose Absorption Regulation Of Intestinal Lipid Absorption	Proteolysis
Pathways		Tight junction interactions	Regulation of CDH11 function
Drugs
Diseases			Asthma
GWAS		Alcoholic chronic pancreatitis ( 28754779) Pancreatitis ( 23143602)	Night sleep phenotypes ( 27126917) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		29 interacting genes: ADAM33 BTN3A2 CLEC2D CSGALNACT2 CXCL9 CYSRT1 EMP3 FAM209A GRM2 IGFBP5 IL27RA KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP4-12 LAT LNX1 LPAR3 MTDH NOTCH2NLA PIAS2 PLP1 TEX264 TJP1 TJP2 TMEM218 UBE2I WNK4	33 interacting genes: AQP9 ASGR2 ATXN7 BTNL9 CD3E CLDN2 CLEC7A CREB3L1 CYB5R3 EPGN FCGR2A GGT6 HIBADH KIR3DL3 LMNA MUC1 NCR1 OPRM1 PLEKHO1 SEC11A SGCB SLC22A23 SLC30A2 SLC35E2A SLC4A1 SPINT1 STOML3 TMEM106C TMEM14B TMEM237 TNFSF14 UBQLN4 VMA21
Entrez ID		9075	80332
HPRD ID		06471	06173
Ensembl ID		ENSG00000165376	ENSG00000149451
Uniprot IDs		P57739	A2A2L3 Q9BZ11
PDB IDs		4YYX	1R54 1R55
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Positive Regulation Of Blood-brain Barrier Permeability Bicellular Tight Junction Regulation Of Blood-brain Barrier Permeability Bleb Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Vascular Permeability	Membrane Plasma Membrane
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