EIF3G and EIF3C

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (biochemical, biochemical)
HPRD (in vitro, in vivo)

		EIF3G	EIF3C
Description		eukaryotic translation initiation factor 3 subunit G	eukaryotic translation initiation factor 3 subunit C
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Translation Initiation Factor Activity Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Viral Translational Termination-reinitiation	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Positive Regulation Of Translation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 23128233 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lamb consumption ( 32066663)
Interacting Genes		29 interacting genes: ACD AIFM1 APP EIF3A EIF3B EIF3C EIF3D EIF3H EIF3K EIF5 EPB41 FAM9B GADD45G GOLGA2 LMNA MEOX2 METTL3 MIF4GD MPHOSPH6 OGT PALS2 PIN1 PKN2 POT1 PRKAG1 SMN1 SNCA TK1 TRIM14	23 interacting genes: AAGAB ALKBH4 BTG3 CALM1 COXFA4L2 DSCAM EIF1AX EIF3E EIF3G EIF3J EIF3K ERCC6 HMOX2 MAPK6 PFDN1 PLEKHF2 RNF10 RPS6KA3 SMAD9 SNCA SNIP1 TACC3 TRAPPC2
Entrez ID		8666	8663
HPRD ID		04886	04889
Ensembl ID		ENSG00000130811	ENSG00000184110
Uniprot IDs		O75821	Q99613
PDB IDs		2CQ0 2MJC 5K0Y 6YBS 6ZMW 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8XXM 8XXN 9BLN	3J8B 3J8C 6YBD 6YBW 6ZMW 6ZON 6ZP4 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Translational Initiation Translation Initiation Factor Activity Protein-containing Complex Assembly Protein-containing Complex Organization Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Cellular Component Assembly Regulation Of Translational Initiation Protein-RNA Complex Assembly Regulation Of Translation Viral Translational Termination-reinitiation Translation Post-transcriptional Regulation Of Gene Expression Cytoplasm IRES-dependent Viral Translational Initiation Macromolecule Metabolic Process Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process RNA Binding Cytosol Telomere Assembly Protein Tetramerization Protein Metabolic Process Nucleus Phosphoprotein Binding Cap-dependent Translational Initiation Shelterin Complex Negative Regulation Of Protein Catabolic Process Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Glycolytic Process Nuclear Telomere Cap Complex Positive Regulation Of Translation Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Biosynthetic Process Telomere Capping Protein-containing Complex Establishment Of Protein Localization To Organelle Regulation Of ATP Metabolic Process Positive Regulation Of Protein Metabolic Process Nuclear Body Regulation Of Purine Nucleotide Metabolic Process Regulation Of Protein Catabolic Process	Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Translation Initiation Factor Activity Translational Initiation Cytoplasmic Translational Initiation Protein-RNA Complex Assembly Regulation Of Acyl-CoA Biosynthetic Process Translation Vesicle-mediated Transport In Synapse Positive Regulation Of Vesicle Fusion
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