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RAI14 and YWHAB
Number of citations of the paper that reports this interaction (PubMedID
35271311
)
106
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
RAI14
YWHAB
Description
retinoic acid induced 14
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Image
No pdb structure
GO Annotations
Cellular Component
Fibrillar Center
Stress Fiber
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Cell Cortex
Anchoring Junction
Nucleus
Cytoplasm
Vacuole
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Protein-containing Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Actin Binding
Protein Binding
Protein Kinase Inhibitor Activity
Protein Phosphatase Inhibitor Activity
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Protein Sequestering Activity
Biological Process
Spermatogenesis
Cell Differentiation
Protein Targeting
Signal Transduction
Intracellular Protein Localization
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Copper
Phenethyl Isothiocyanate
Diseases
GWAS
Age-related cognitive decline (attention/processing speed) (slope of z-scores) (
30954325
)
Blood urea nitrogen levels (
31152163
)
Chronic kidney disease (
31152163
)
Creatinine levels (
29403010
)
Daytime sleep phenotypes (
27126917
)
Estimated glomerular filtration rate (
31152163
31451708
31015462
30604766
)
Estimated glomerular filtration rate in diabetes (
31451708
)
Glomerular filtration rate (
29403010
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
LDL cholesterol levels (
32203549
)
Left ventricular mass (
19454037
)
Platelet count (
32888494
)
Red blood cell count (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Serum uric acid levels (
30993211
)
Urate levels (
31578528
)
Waist circumference adjusted for BMI (adjusted for smoking behaviour) (
28443625
)
Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) (
28443625
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Interacting Genes
8 interacting genes:
FEZ1
FEZ2
ITSN1
TTC3
USP7
YWHAB
YWHAG
YWHAQ
147 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FILNC1
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
NCAM2
NEDD4L
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PDE4B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RIPK2
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
Entrez ID
26064
7529
HPRD ID
09416
03184
Ensembl ID
ENSG00000039560
ENSG00000166913
Uniprot IDs
Q9P0K7
P31946
V9HWD6
PDB IDs
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
8DP5
8EQ8
8EQH
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Autophagy
Negative Regulation Of Autophagosome Assembly
Protein Domain Specific Binding
Protein Targeting
Regulation Of Intracellular Transport
Protein Sequestering Activity
Protein Kinase C Binding
Negative Regulation Of Macroautophagy
Regulation Of Autophagosome Assembly
Regulation Of Transport
Negative Regulation Of Metabolic Process
Negative Regulation Of TORC1 Signaling
TORC1 Signaling
Regulation Of Vacuole Organization
Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion
Negative Regulation Of Catabolic Process
Regulation Of Autophagy
TOR Signaling
Cytoplasm
Focal Adhesion
Negative Regulation Of TOR Signaling
Clathrin-dependent Synaptic Vesicle Endocytosis
Regulation Of TORC1 Signaling
Regulation Of Cellular Localization
Protein Kinase C Inhibitor Activity
Symbiont-mediated Disruption Of Host Cell PML Body
Establishment Of Protein Localization
Positive Regulation Of Caveolin-mediated Endocytosis
Regulation Of TOR Signaling
Protein Ubiquitination
Phosphoserine Residue Binding
Regulation Of Establishment Of Protein Localization To Telomere
Regulation Of Caveolin-mediated Endocytosis
Regulation Of Modification Of Postsynaptic Actin Cytoskeleton
Protein Modification By Small Protein Conjugation
Regulation Of Establishment Of Protein Localization To Chromosome
Regulation Of Retrograde Transport, Endosome To Golgi
Regulation Of Macroautophagy
Postsynaptic Endocytic Zone
Signal Transduction
Positive Regulation Of Growth Hormone Secretion
Protein-containing Complex
Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell
Monoubiquitinated Protein Deubiquitination
Regulation Of Organelle Transport Along Microtubule
Axon Guidance
Neuron Projection Guidance
Postsynaptic Actin Cytoskeleton
Phosphorylation-dependent Protein Binding
Protein Stabilization
Kinase Activity
Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Cytosol
Protein Serine Kinase Activity
Regulation Of Cell Communication
Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Cytoplasm
Protein Phosphorylation
ATP Binding
Positive Regulation Of Signaling
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Positive Regulation Of Intracellular Signal Transduction
Nucleotide Binding
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Signal Transduction
Cellular Response To Oxygen-containing Compound
Protein Tyrosine Kinase Activity
Response To Stress
Cellular Response To Stress
Regulation Of Cell Cycle
Regulation Of Membrane Potential
Intracellular Signaling Cassette
Cellular Response To Hormone Stimulus
Cadherin Binding
Regulation Of Protein-containing Complex Assembly
Regulation Of Phosphorus Metabolic Process
Cellular Response To Insulin Stimulus
Regulation Of Protein Phosphorylation
Regulation Of Biological Quality
Plasma Membrane
Response To Insulin
Positive Regulation Of Catabolic Process
Phosphate-containing Compound Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Regulation Of Phosphorylation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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