RAI14 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RAI14	TTC3
Description		retinoic acid induced 14	tetratricopeptide repeat domain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Cell Cortex Anchoring Junction	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Actin Binding Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Spermatogenesis Cell Differentiation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways
Drugs
Diseases
GWAS		Age-related cognitive decline (attention/processing speed) (slope of z-scores) ( 30954325) Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate ( 31152163 31451708 31015462 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels ( 32203549) Left ventricular mass ( 19454037) Platelet count ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum uric acid levels ( 30993211) Urate levels ( 31578528) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)	Eye color traits ( 20463881)
Interacting Genes		8 interacting genes: FEZ1 FEZ2 ITSN1 TTC3 USP7 YWHAB YWHAG YWHAQ	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		26064	7267
HPRD ID		09416	03773
Ensembl ID		ENSG00000039560	ENSG00000182670
Uniprot IDs		Q9P0K7	H7BZ57 P53804
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Autophagy Negative Regulation Of Autophagosome Assembly Protein Domain Specific Binding Protein Targeting Regulation Of Intracellular Transport Protein Sequestering Activity Protein Kinase C Binding Negative Regulation Of Macroautophagy Regulation Of Autophagosome Assembly Regulation Of Transport Negative Regulation Of Metabolic Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Vacuole Organization Positive Regulation Of Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Catabolic Process Regulation Of Autophagy TOR Signaling Cytoplasm Focal Adhesion Negative Regulation Of TOR Signaling Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of TORC1 Signaling Regulation Of Cellular Localization Protein Kinase C Inhibitor Activity Symbiont-mediated Disruption Of Host Cell PML Body Establishment Of Protein Localization Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of TOR Signaling Protein Ubiquitination Phosphoserine Residue Binding Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Caveolin-mediated Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Protein Modification By Small Protein Conjugation Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Macroautophagy Postsynaptic Endocytic Zone Signal Transduction Positive Regulation Of Growth Hormone Secretion Protein-containing Complex Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Monoubiquitinated Protein Deubiquitination Regulation Of Organelle Transport Along Microtubule Axon Guidance Neuron Projection Guidance Postsynaptic Actin Cytoskeleton Phosphorylation-dependent Protein Binding Protein Stabilization	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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