SGCG and MYBPC1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		SGCG	MYBPC1
Description		sarcoglycan gamma	myosin binding protein C1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma	Cytosol Myofibril M Band Myosin Filament
	Molecular Function	Protein Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding
	Biological Process	Muscle Organ Development Gene Expression Cardiac Muscle Tissue Development Heart Contraction	Cell Adhesion Sarcomere Organization
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Striated Muscle Contraction
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Alanine aminotransferase levels ( 31219225) Aspartate aminotransferase levels ( 33547301) Asthma ( 27611488) Atrial fibrillation ( 30061737) Bipolar disorder ( 21738484) Central corneal thickness ( 29760442) Corneal structure ( 23291589) Number of alcoholic drinks required to feel an effect (first five times drinking) ( 31270906) Recurrent major depressive disorder x sex interaction ( 34099189) Type 2 diabetes ( 23300278)	Lung function (FEV1) ( 24023788) Memory decline ( 31985465)
Interacting Genes		20 interacting genes: APP CCT6A CLDN5 DNAJB6 DYSF ENO1 ENO3 FLNC HSPA1B MYBPC1 MYBPC2 MYL11 PSAP PYGM SGCB SGCD SPACA1 SSPN SUCLG2 TTN	27 interacting genes: ACO1 AMOT ANKRD1 ASH2L C1QTNF9 CALM1 CAPN3 CLIP4 DNAJB5 DNAJB6 DYSF FHL1 FHL2 FHL3 GABARAP GABARAPL1 GABARAPL2 KLHL41 MAP1LC3A MEOX2 MYBPC2 NCF1 RAF1 SGCG TRIM55 TRIM63 TTN
Entrez ID		6445	4604
HPRD ID		07039	01185
Ensembl ID		ENSG00000102683	ENSG00000196091
Uniprot IDs		Q13326	A8KAB1 B3KPP3 Q00872
PDB IDs			1X44 2DAV 2YUV 2YUW 2YUX 2YUZ 2YXM
Enriched GO Terms of Interacting Partners?		M Band Sarcolemma Sarcomere Organization Structural Constituent Of Muscle Actin Filament-based Process Dystrophin-associated Glycoprotein Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Muscle Cell Development Actomyosin Structure Organization Cardiac Muscle Cell Development Dystroglycan Complex Actin-mediated Cell Contraction Cardiac Cell Development Sarcoglycan Complex Protein Folding Chaperone Actin Cytoskeleton Organization Actin Filament-based Movement Negative Regulation Of Inclusion Body Assembly Striated Muscle Cell Development Muscle Contraction Actin-myosin Filament Sliding Muscle System Process Extracellular Exosome Canonical Glycolysis Unfolded Protein Binding Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Carbohydrate Catabolic Process Regulation Of Inclusion Body Assembly Myosin Filament Cell Adhesion Cell Development Nucleoside Phosphate Catabolic Process Glucose Catabolic Process Z Disc Nucleobase-containing Compound Catabolic Process ATP-dependent Protein Folding Chaperone Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway System Process ATP Metabolic Process Organophosphate Catabolic Process Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity	Cellular Response To Nitrogen Starvation Titin Binding Phosphatidylethanolamine Binding Actin Cytoskeleton Organization Z Disc M Band Cytoskeleton Organization Actin Filament-based Process Sarcomere Organization Actomyosin Structure Organization Autophagosome Maturation Phospholipid Binding Autophagosome Membrane Mitophagy GABA Receptor Binding Autophagy Of Mitochondrion Organelle Organization Autophagosome Response To Muscle Stretch Myofibril Assembly Autophagosome Assembly Autophagosome Organization Adenylate Cyclase Activator Activity Beta-tubulin Binding Structural Constituent Of Muscle Muscle Organ Development Response To Iron(II) Ion Muscle Structure Development Protein-containing Complex Disassembly Organelle Assembly Cytoplasm Macroautophagy Response To Metal Ion Vacuole Organization Microtubule Cellular Response To Starvation Pseudopodium Response To Starvation Cellular Response To Nutrient Levels Cytosol I Band Supramolecular Fiber Organization Response To Iron Ion Autophagy Response To Calcium Ion Ubiquitin Protein Ligase Binding Anatomical Structure Formation Involved In Morphogenesis Protein Binding Calcium-dependent Self Proteolysis Monocyte Activation Involved In Immune Response
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