SGCG and HSPA1B

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		SGCG	HSPA1B
Description		sarcoglycan gamma	heat shock protein family A (Hsp70) member 1B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleotide Binding Virus Receptor Activity G Protein-coupled Receptor Binding RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Protein Folding Chaperone Unfolded Protein Binding C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone
	Biological Process	Muscle Organ Development Gene Expression Cardiac Muscle Tissue Development Heart Contraction	MRNA Catabolic Process Protein Folding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Symbiont Entry Into Host Cell Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Regulation Of Mitotic Spindle Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt) Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Alanine aminotransferase levels ( 31219225) Aspartate aminotransferase levels ( 33547301) Asthma ( 27611488) Atrial fibrillation ( 30061737) Bipolar disorder ( 21738484) Central corneal thickness ( 29760442) Corneal structure ( 23291589) Number of alcoholic drinks required to feel an effect (first five times drinking) ( 31270906) Recurrent major depressive disorder x sex interaction ( 34099189) Type 2 diabetes ( 23300278)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Eosinophilic esophagitis ( 29904099) Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 32771030) Ulcerative colitis ( 28067908)
Interacting Genes		20 interacting genes: APP CCT6A CLDN5 DNAJB6 DYSF ENO1 ENO3 FLNC HSPA1B MYBPC1 MYBPC2 MYL11 PSAP PYGM SGCB SGCD SPACA1 SSPN SUCLG2 TTN	25 interacting genes: AIFM1 BAG1 BAG4 BNIP2 CEBPA DNMBP F2RL1 FAF1 FTCD HSPBP1 MYBPC2 NEDD8 PGAM5 SGCG SNCA ST13 STUB1 SUMO4 TGM2 TOMM70 TRIM38 TTN UBQLN2 YWHAB YWHAZ
Entrez ID		6445	3304
HPRD ID		07039	06784
Ensembl ID		ENSG00000102683	ENSG00000204388
Uniprot IDs		Q13326	A8K5I0 P0DMV8 P0DMV9
PDB IDs			1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39 6ZYI 7F4X 7F4Z 7F50 7FGM 7GY4 7GY5 7GY6 7GY7 7GY8 7GY9 7GYA 7GYB 7GYC 7GYD 7GYE 7GYF 7GYG 7GYH 7GYI 7GYJ 7GYK 7GYL 7GYM 7GYN 7GYO 7GYP 7GYQ 7GYR 7GYS 7GYT 7GYU 7GYV 7GYW 7GYX 7KW7 7Q4R
Enriched GO Terms of Interacting Partners?		M Band Sarcolemma Sarcomere Organization Structural Constituent Of Muscle Actin Filament-based Process Dystrophin-associated Glycoprotein Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Muscle Cell Development Actomyosin Structure Organization Cardiac Muscle Cell Development Dystroglycan Complex Actin-mediated Cell Contraction Cardiac Cell Development Sarcoglycan Complex Protein Folding Chaperone Actin Cytoskeleton Organization Actin Filament-based Movement Negative Regulation Of Inclusion Body Assembly Striated Muscle Cell Development Muscle Contraction Actin-myosin Filament Sliding Muscle System Process Extracellular Exosome Canonical Glycolysis Unfolded Protein Binding Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Carbohydrate Catabolic Process Regulation Of Inclusion Body Assembly Myosin Filament Cell Adhesion Cell Development Nucleoside Phosphate Catabolic Process Glucose Catabolic Process Z Disc Nucleobase-containing Compound Catabolic Process ATP-dependent Protein Folding Chaperone Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway System Process ATP Metabolic Process Organophosphate Catabolic Process Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity	Ubiquitin Protein Ligase Binding Adenyl-nucleotide Exchange Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Protein Folding Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Protein Domain Specific Binding Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization Phosphoserine Residue Binding Cytosol Protein Sequestering Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Hsp70 Protein Binding Positive Regulation Of Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Protein Stability Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Protein Tag Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase Regulator Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Smooth Muscle Cell Apoptotic Process Response To Alkaloid Positive Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Cell Communication Regulation Of Signaling Dopamine Transport Perinuclear Region Of Cytoplasm Protein-folding Chaperone Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process M Band Regulation Of ERAD Pathway Negative Regulation Of Apoptotic Process Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Establishment Of Protein Localization Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium
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