SGCG and SPACA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGCG	SPACA1
Description		sarcoglycan gamma	sperm acrosome associated 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma	Acrosomal Vesicle Inner Acrosomal Membrane Acrosomal Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Muscle Organ Development Gene Expression Cardiac Muscle Tissue Development Heart Contraction	Acrosome Assembly Spermatogenesis
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS		Alanine aminotransferase levels ( 31219225) Aspartate aminotransferase levels ( 33547301) Asthma ( 27611488) Atrial fibrillation ( 30061737) Bipolar disorder ( 21738484) Central corneal thickness ( 29760442) Corneal structure ( 23291589) Number of alcoholic drinks required to feel an effect (first five times drinking) ( 31270906) Recurrent major depressive disorder x sex interaction ( 34099189) Type 2 diabetes ( 23300278)	Echocardiographic traits ( 17903301) Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676) Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429)
Interacting Genes		20 interacting genes: APP CCT6A CLDN5 DNAJB6 DYSF ENO1 ENO3 FLNC HSPA1B MYBPC1 MYBPC2 MYL11 PSAP PYGM SGCB SGCD SPACA1 SSPN SUCLG2 TTN	25 interacting genes: AGPAT4 ATP6V0B ATP6V0C BNIP3 CACNG7 CD72 CLDN19 CTXN3 EMP1 EMP3 GIMAP5 LSMEM2 NRSN1 NSG1 PLN PMP22 RPRM SERP2 SERTM1 SGCG SMAGP SMIM3 THSD7B TMEM140 TMEM47
Entrez ID		6445	81833
HPRD ID		07039	15419
Ensembl ID		ENSG00000102683	ENSG00000118434
Uniprot IDs		Q13326	Q9HBV2
PDB IDs
Enriched GO Terms of Interacting Partners?		M Band Sarcolemma Sarcomere Organization Structural Constituent Of Muscle Actin Filament-based Process Dystrophin-associated Glycoprotein Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Muscle Cell Development Actomyosin Structure Organization Cardiac Muscle Cell Development Dystroglycan Complex Actin-mediated Cell Contraction Cardiac Cell Development Sarcoglycan Complex Protein Folding Chaperone Actin Cytoskeleton Organization Actin Filament-based Movement Negative Regulation Of Inclusion Body Assembly Striated Muscle Cell Development Muscle Contraction Actin-myosin Filament Sliding Muscle System Process Extracellular Exosome Canonical Glycolysis Unfolded Protein Binding Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate Carbohydrate Catabolic Process Regulation Of Inclusion Body Assembly Myosin Filament Cell Adhesion Cell Development Nucleoside Phosphate Catabolic Process Glucose Catabolic Process Z Disc Nucleobase-containing Compound Catabolic Process ATP-dependent Protein Folding Chaperone Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway System Process ATP Metabolic Process Organophosphate Catabolic Process Ganglioside GM3 Binding Ganglioside GP1c Binding Positive Regulation Of Beta-galactosidase Activity	Membrane Bleb Assembly Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Endosomal Lumen Acidification Proton-transporting V-type ATPase Complex Proton Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism Lysosomal Lumen Acidification Endosome Membrane Multivesicular Body Membrane Clathrin-coated Vesicle Membrane Regulation Of Lysosomal Lumen PH Vacuolar Acidification Mitochondrion Autophagosome Adaptor Activity Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Postsynaptic Neurotransmitter Receptor Cycle Neurotransmitter Receptor Cycle
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