SGCG and FLNC

Number of citations of the paper that reports this interaction (PMID 10629222)
36

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SGCG	FLNC
Gene Name		sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)	filamin C, gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Sarcoglycan Complex Integral Component Of Membrane Sarcolemma	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function	Protein Binding	Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Muscle Organ Development Cardiac Muscle Tissue Development Muscle Cell Development Heart Contraction Membrane Organization	Cell Junction Assembly Muscle Fiber Development
Pathways			Cell junction organization Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Bipolar disorder ( 21738484) Corneal structure ( 23291589) Type 2 diabetes ( 23300278)
Protein-Protein Interactions		7 interactors: APP CDK8 EP300 FLNC SGCB SGCD SSPN	29 interactors: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 INPPL1 KCND2 KY MAP2K4 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		6445	2318
HPRD ID		07039	00018
Ensembl ID		ENSG00000102683	ENSG00000128591
Uniprot IDs		Q13326	Q14315 Q59H94
PDB IDs			1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Notch Signaling Pathway Muscle Cell Development Muscle Organ Development Striated Muscle Tissue Development Muscle Cell Differentiation Muscle Fiber Development Muscle Tissue Development Histone H2B Acetylation Heart Development Synaptic Growth At Neuromuscular Junction Regulation Of Protein Binding Collateral Sprouting In Absence Of Injury N-terminal Peptidyl-lysine Acetylation Striated Muscle Cell Development Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Cardiac Muscle Tissue Development Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Tubulin Deacetylation Cardiovascular System Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell Cycle Striated Muscle Cell Differentiation Axon Choice Point Recognition Regulation Of Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter Neuron Remodeling Positive Regulation By Host Of Viral Transcription Vascular Smooth Muscle Cell Development N-terminal Protein Amino Acid Acetylation	Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Muscle Cell Development Blood Circulation Muscle Structure Development Heart Development Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Cardiovascular System Development Positive Regulation Of Systemic Arterial Blood Pressure Adrenergic Receptor Signaling Pathway Muscle Cell Differentiation Regulation Of Blood Pressure Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cardiac Muscle Tissue Development Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Organ Development Multicellular Organismal Development Developmental Process Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Muscle Organ Development Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Peptidyl-threonine Phosphorylation Striated Muscle Tissue Development Striated Muscle Cell Development System Development Muscle Tissue Development Regulation Of Heart Contraction Anatomical Structure Development Actin Cytoskeleton Organization Regulation Of The Force Of Heart Contraction By Chemical Signal Heart Contraction Actin Filament-based Process Myofibril Assembly Cell Development Regulation Of Blood Vessel Size Cellular Response To Carbohydrate Stimulus Regulation Of Tube Size Striated Muscle Cell Differentiation Adult Heart Development Muscle System Process Signaling Organ Growth Actomyosin Structure Organization Cell Communication Positive Regulation Of Heart Rate Peptidyl-serine Phosphorylation
Tagcloud ?		accumulate alterations anaplastic astrocytoma consequence correlations cps1 genomic glial glioblastoma glioma gp2 htr4 implies inpp5a instability itgb1 kcng2 kir3dl3 lhfpl3 p16 passenger pathogenesis pde4d predominantly pros1 pten seem subtypes	adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Difference) ?		accumulate alterations anaplastic astrocytoma consequence correlations cps1 genomic glial glioblastoma glioma gp2 htr4 implies inpp5a instability itgb1 kcng2 kir3dl3 lhfpl3 p16 passenger pathogenesis pde4d predominantly pros1 pten seem subtypes	adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Intersection) ?