PCNX4 and CEP63

Number of citations of the paper that reports this interaction (PubMedID 17043677)
0

Data Source:
BioGRID (two hybrid)

		PCNX4	CEP63
Description		pecanex 4	centrosomal protein 63
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Spindle Pole Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body
	Molecular Function	Protein Binding	Protein Binding Molecular Adaptor Activity
	Biological Process		DNA Damage Checkpoint Signaling DNA Damage Response Centriole Replication Proteasomal Protein Catabolic Process Signal Transduction In Response To DNA Damage Innate Immune Response Negative Regulation Of Innate Immune Response Protein Stabilization Spindle Assembly Cell Division De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation Negative Regulation Of Protein K63-linked Ubiquitination
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Height ( 18391952) Hip circumference adjusted for BMI ( 34021172) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		4 interacting genes: CEP63 DISC1 FBP1 MTNR1B	66 interacting genes: ALOX5 ARFIP2 ARNT2 BFSP2 BRPF1 CAMKK2 CAPN7 CCDC14 CCDC187 CCHCR1 CCNI CDK1 CEP57 CEP57L1 CWF19L2 DAXX DISC1 DSCAM DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 FEM1C GSE1 HAUS1 HGS INTS6L KANK2 KXD1 MACF1 MBIP MNS1 NCOR2 NDC80 NDEL1 NXT2 PCNX4 PIBF1 POLR3C PPP1R13B PPP4R1 RCOR3 ROGDI SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TBC1D22B TSG101 TSGA10IP TSHZ3 TXLNA USHBP1 USP2 ZCCHC10 ZNF148 ZNF250 ZNF774
Entrez ID		64430	80254
HPRD ID		16604	07826
Ensembl ID		ENSG00000126773	ENSG00000182923
Uniprot IDs		B6ZDM2 Q63HM2	A0A804HIX3 A0A804HKK0 A0A804HKR1 A0A804HL17 H0YAL1 Q96MT8
PDB IDs			6CSU 6CSV 7W91
Enriched GO Terms of Interacting Partners?		Cellular Hypotonic Salinity Response Hyperosmotic Salinity Response Cellular Hyperosmotic Salinity Response Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Cellular Response To Magnesium Ion Fructose 1,6-bisphosphate 1-phosphatase Activity Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Radial Glia-guided Pyramidal Neuron Migration Pyramidal Neuron Migration To Cerebral Cortex Molecular Adaptor Activity Central Region Of Growth Cone Negative Regulation Of Protein K63-linked Ubiquitination De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Proline Racemase Activity Trans-L-3-hydroxyproline Dehydratase Activity Hydro-lyase Activity Fructose 1,6-bisphosphate Metabolic Process Monosaccharide Binding Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cerebral Cortex Radial Glia-guided Migration Negative Regulation Of Protein Polyubiquitination Cellular Hypotonic Response Cellular Response To Salt Stress Cellular Response To Phorbol 13-acetate 12-myristate Ciliary Basal Body Hypotonic Response AMP Binding Response To Phorbol 13-acetate 12-myristate Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Regulation Of Protein K63-linked Ubiquitination Cell Proliferation In Forebrain Regulation Of Cell Growth Cellular Hyperosmotic Response Response To Magnesium Ion Negative Regulation Of Glycolytic Process Response To Salt Stress Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Transmission Of Nerve Impulse	Centrosome Cytoskeleton Cytoskeleton Organization Microtubule Cytoskeleton Organization Microtubule Binding Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Assembly Microtubule-based Process Nuclear Matrix Protein Binding Organelle Organization Cilium Organization Protein Localization To Centrosome Radial Glia-guided Pyramidal Neuron Migration Polymeric Cytoskeletal Fiber Cyclin Binding Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Mitotic Cohesin Complex Microtubule Intermediate Filament Cytoskeleton Organization Positive Regulation Of Developmental Growth Chromosome, Centromeric Region Positive Regulation Of Axon Extension Organelle Assembly Establishment Of Sister Chromatid Cohesion Spindle Organization Mitotic Spindle Pole Intermediate Filament-based Process Spectrin Mitotic Spindle Organization Mitotic Spindle Assembly Membrane Fission Negative Regulation Of Actin Filament Polymerization Protein Localization To Cytoskeleton Locomotor Rhythm
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