KCNMA1 and HMOX2

Number of citations of the paper that reports this interaction (PMID 15528406)
83

Data Source:
HPRD (in vitro)

		KCNMA1	HMOX2
Gene Name		potassium channel, calcium activated large conductance subfamily M alpha, member 1	heme oxygenase (decycling) 2
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Actin Binding Voltage-gated Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity	Heme Oxygenase (decyclizing) Activity Protein Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Potassium Ion Transport Response To Osmotic Stress Synaptic Transmission Blood Coagulation Cellular Potassium Ion Homeostasis Response To Carbon Monoxide Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Micturition Smooth Muscle Contraction Involved In Micturition Potassium Ion Transmembrane Transport	Response To Hypoxia Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Heme Catabolic Process Small Molecule Metabolic Process Transmembrane Transport
Pathways		Ca2+ activated K+ channels Platelet homeostasis Potassium Channels Nitric oxide stimulates guanylate cyclase cGMP effects	Iron uptake and transport Metabolism of porphyrins Heme degradation
Drugs		Enflurane Chlorzoxazone Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Cromoglicic acid Miconazole Diazoxide Halothane	NADH
Diseases
GWAS		Bone mineral density ( 22504420) Mortality among heart failure patients ( 20400778) Obesity ( 21708048)
Protein-Protein Interactions		6 interactors: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2	32 interactors: A2M APP ATP5B BLOC1S2 CEBPZ COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 KIAA1377 LRIF1 MED31 NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746
Entrez ID		3778	3163
HPRD ID		15967	00783
Ensembl ID		ENSG00000156113	ENSG00000103415
Uniprot IDs		B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ8 Q6AI34 S4R453	I3L430 P30519
PDB IDs		2K44 3MT5 3NAF	2Q32 2QPP 2RGZ
Enriched GO Terms of Interacting Partners?		Glutathione Catabolic Process Aldosterone Biosynthetic Process Cortisol Biosynthetic Process Heme Oxidation Netrin-activated Signaling Pathway Cysteine Biosynthetic Process Positive Regulation Of Acrosome Reaction Mineralocorticoid Biosynthetic Process Negative Regulation Of Synapse Assembly Cellular Response To Potassium Ion Signal Complex Assembly Heme Catabolic Process Cysteine Metabolic Process Response To Potassium Ion Glucocorticoid Biosynthetic Process Regulation Of Acrosome Reaction Response To Metal Ion Detection Of Calcium Ion	Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Axon Cargo Transport Cellular Macromolecule Biosynthetic Process Organelle Organization Macromolecule Biosynthetic Process RNA Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Process Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor Activity Cell Projection Organization Cellular Nitrogen Compound Metabolic Process Anterograde Axon Cargo Transport Microtubule-based Transport Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Body Fluid Levels Cytoskeleton-dependent Intracellular Transport Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Glucocorticoid Mediated Signaling Pathway Positive Regulation Of Renal Water Transport Regulation Of Cellular Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Cellular Response To CAMP Cellular Homeostasis Regulation Of Mitotic Cell Cycle Platelet Activation
Tagcloud ?		10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Difference) ?		10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Intersection) ?