KCNMA1 and GGT1

Number of citations of the paper that reports this interaction (PMID 15528406)
83

Data Source:
HPRD (in vitro)

		KCNMA1	GGT1
Gene Name		potassium channel, calcium activated large conductance subfamily M alpha, member 1	gamma-glutamyltransferase 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Extracellular Vesicular Exosome	Extracellular Space Plasma Membrane Integral Component Of Membrane Anchored Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Voltage-gated Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity	Gamma-glutamyltransferase Activity Protein Binding Glutathione Hydrolase Activity
	Biological Process	Response To Hypoxia Potassium Ion Transport Response To Osmotic Stress Synaptic Transmission Blood Coagulation Cellular Potassium Ion Homeostasis Response To Carbon Monoxide Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Micturition Smooth Muscle Contraction Involved In Micturition Potassium Ion Transmembrane Transport	Regulation Of Immune System Process Proteolysis Cellular Amino Acid Metabolic Process Glutamate Metabolic Process Leukotriene Metabolic Process Glutathione Metabolic Process Glutathione Biosynthetic Process Glutathione Catabolic Process Xenobiotic Metabolic Process Spermatogenesis Cysteine Biosynthetic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Zymogen Activation Small Molecule Metabolic Process Regulation Of Inflammatory Response Glutathione Derivative Biosynthetic Process
Pathways		Ca2+ activated K+ channels Platelet homeostasis Potassium Channels Nitric oxide stimulates guanylate cyclase cGMP effects	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Aflatoxin activation and detoxification Defective UGT1A4 causes hyperbilirubinemia Glutathione synthesis and recycling Synthesis of Leukotrienes (LT) and Eoxins (EX) Metabolic disorders of biological oxidation enzymes Glutathione conjugation Arachidonic acid metabolism Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective ACY1 causes encephalopathy Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Enflurane Chlorzoxazone Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Cromoglicic acid Miconazole Diazoxide Halothane	Glutathione
Diseases
GWAS		Bone mineral density ( 22504420) Mortality among heart failure patients ( 20400778) Obesity ( 21708048)	Gamma glutamyl transpeptidase ( 21909109) Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		6 interactors: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2	3 interactors: CD53 KCNMA1 NAMPT
Entrez ID		3778	2678
HPRD ID		15967	01980
Ensembl ID		ENSG00000156113	ENSG00000100031
Uniprot IDs		B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ8 Q6AI34 S4R453	P19440
PDB IDs		2K44 3MT5 3NAF	4GDX 4GG2
Enriched GO Terms of Interacting Partners?		Glutathione Catabolic Process Aldosterone Biosynthetic Process Cortisol Biosynthetic Process Heme Oxidation Netrin-activated Signaling Pathway Cysteine Biosynthetic Process Positive Regulation Of Acrosome Reaction Mineralocorticoid Biosynthetic Process Negative Regulation Of Synapse Assembly Cellular Response To Potassium Ion Signal Complex Assembly Heme Catabolic Process Cysteine Metabolic Process Response To Potassium Ion Glucocorticoid Biosynthetic Process Regulation Of Acrosome Reaction Response To Metal Ion Detection Of Calcium Ion	Negative Regulation Of Cell Volume Smooth Muscle Contraction Involved In Micturition Response To Carbon Monoxide Nicotinamide Metabolic Process Micturition Cellular Potassium Ion Homeostasis Urinary Bladder Smooth Muscle Contraction Alkaloid Metabolic Process Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Potassium Ion Homeostasis Positive Regulation Of Myoblast Fusion Regulation Of Myoblast Fusion Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion NAD Biosynthetic Process Cell Volume Homeostasis Positive Regulation Of Myotube Differentiation Cell-cell Signaling Excretion NAD Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Myotube Differentiation Smooth Muscle Contraction Positive Regulation Of Striated Muscle Cell Differentiation Circadian Regulation Of Gene Expression Nicotinamide Nucleotide Metabolic Process Water-soluble Vitamin Metabolic Process Positive Regulation Of Muscle Cell Differentiation Response To Osmotic Stress Renal System Process Regulation Of Striated Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Proliferation Signaling Vitamin Metabolic Process Cell Communication
Tagcloud ?		10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc22a1 slc22a2 slc22a6 slc22a8 slc47a1 wu
Tagcloud (Difference) ?		10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	4alpha ahn brush cyp2d2 cyp2d4 dme dmes fmo1 handled hnf1a hnf4a massively mate1 metabolizing nfe2l2 nigam nqo2 nr3c1 oat1 oat3 oct1 oct2 pt slc22a1 slc22a2 slc22a6 slc22a8 slc47a1 wu
Tagcloud (Intersection) ?