KCNMA1 and CACNA1H

Number of citations of the paper that reports this interaction (PMID 14631046)
44

Data Source:
HPRD (in vivo)

		KCNMA1	CACNA1H
Gene Name		potassium channel, calcium activated large conductance subfamily M alpha, member 1	calcium channel, voltage-dependent, T type, alpha 1H subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Caveola Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Voltage-gated Calcium Channel Complex Caveola Integral Component Of Membrane Sarcolemma
	Molecular Function	Actin Binding Voltage-gated Potassium Channel Activity Protein Binding Calcium-activated Potassium Channel Activity Metal Ion Binding Large Conductance Calcium-activated Potassium Channel Activity	Low Voltage-gated Calcium Channel Activity Metal Ion Binding Scaffold Protein Binding
	Biological Process	Response To Hypoxia Potassium Ion Transport Response To Osmotic Stress Synaptic Transmission Blood Coagulation Cellular Potassium Ion Homeostasis Response To Carbon Monoxide Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Volume Response To Calcium Ion Micturition Smooth Muscle Contraction Involved In Micturition Potassium Ion Transmembrane Transport	Transport Muscle Contraction Axon Guidance Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Aldosterone Biosynthetic Process Cellular Response To Hormone Stimulus Cortisol Biosynthetic Process Regulation Of Ion Transmembrane Transport Cellular Response To Potassium Ion Regulation Of Membrane Potential Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Positive Regulation Of Acrosome Reaction
Pathways		Ca2+ activated K+ channels Platelet homeostasis Potassium Channels Nitric oxide stimulates guanylate cyclase cGMP effects	NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs		Enflurane Chlorzoxazone Bendroflumethiazide Hydroflumethiazide Hydrochlorothiazide Cromoglicic acid Miconazole Diazoxide Halothane	Isradipine Cinnarizine Zonisamide Felodipine Nitrendipine Nifedipine Amiodarone Bepridil Mibefradil Flunarizine
Diseases
GWAS		Bone mineral density ( 22504420) Mortality among heart failure patients ( 20400778) Obesity ( 21708048)
Protein-Protein Interactions		6 interactors: CACNA1H GGT1 HMOX2 KCNMB1 MAP1A PTK2	2 interactors: GNG2 KCNMA1
Entrez ID		3778	8912
HPRD ID		15967	07442
Ensembl ID		ENSG00000156113	ENSG00000196557
Uniprot IDs		B7ZMF5 D5MRH1 Q12791 Q59FH2 Q5SVJ8 Q6AI34 S4R453	B3KQH9 O95180
PDB IDs		2K44 3MT5 3NAF
Enriched GO Terms of Interacting Partners?		Glutathione Catabolic Process Aldosterone Biosynthetic Process Cortisol Biosynthetic Process Heme Oxidation Netrin-activated Signaling Pathway Cysteine Biosynthetic Process Positive Regulation Of Acrosome Reaction Mineralocorticoid Biosynthetic Process Negative Regulation Of Synapse Assembly Cellular Response To Potassium Ion Signal Complex Assembly Heme Catabolic Process Cysteine Metabolic Process Response To Potassium Ion Glucocorticoid Biosynthetic Process Regulation Of Acrosome Reaction Response To Metal Ion Detection Of Calcium Ion	Negative Regulation Of Cell Volume Smooth Muscle Contraction Involved In Micturition Response To Carbon Monoxide Blood Coagulation Hemostasis Micturition Regulation Of Body Fluid Levels Synaptic Transmission Wound Healing Cellular Potassium Ion Homeostasis Urinary Bladder Smooth Muscle Contraction Response To Wounding Cellular Response To Prostaglandin E Stimulus Potassium Ion Homeostasis Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Cellular Response To Catecholamine Stimulus Cell Volume Homeostasis Dopamine Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Cellular Response To Fatty Acid Excretion Response To Glucagon Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Smooth Muscle Contraction Response To Fatty Acid Response To Osmotic Stress Renal System Process Response To Calcium Ion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Acid Chemical Potassium Ion Transmembrane Transport Platelet Activation Potassium Ion Transport Muscle Contraction Response To Stress Muscle System Process
Tagcloud ?		10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	altering arborization biophysical blocker burst c456s cav3 changing channels dendrites dendritic determinants electrical epilepsy ethosuximide excitability firing generalized goals idiopathic indirectly influences oscillations p2 rebound seizure substantially transactivator tta
Tagcloud (Difference) ?		10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	altering arborization biophysical blocker burst c456s cav3 changing channels dendrites dendritic determinants electrical epilepsy ethosuximide excitability firing generalized goals idiopathic indirectly influences oscillations p2 rebound seizure substantially transactivator tta
Tagcloud (Intersection) ?