IPO7 and LIMS1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		IPO7	LIMS1
Description		importin 7	LIM zinc finger domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Protein Binding GTPase Regulator Activity Small GTPase Binding Histone Binding SMAD Binding	Actin Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Innate Immune Response Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Odontoblast Differentiation	Epithelial To Mesenchymal Transition Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of DNA-templated Transcription Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways			Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases
GWAS		Interleukin-10 levels ( 22205395)	Apolipoprotein B levels ( 32203549) Beard thickness ( 26926045) Birth weight ( 31043758) Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		14 interacting genes: AKTIP CEBPA H1-0 KPNB1 LIMS1 LINC01554 NOSIP PTEN RAN RNF10 RPL23A RPL5 RPS7 SRP19	47 interacting genes: ADAMTS9 ATXN10 CATSPER1 CCN2 COL8A1 CSRP3 CWF19L2 DAPK1 EHMT2 FAM90A1 FERMT2 FERMT3 FMR1 GEM ILK INO80B IPO7 KPRP LMO3 LPXN MBIP MYO15B NCK2 NEB OSR2 PARVA PEG3 PLCE1 RAD51D RBBP8 RSU1 SCNM1 SMURF1 TBC1D22B TCEA2 TGFBR1 TMSB4X TRIO TTN USP11 ZIM2 ZMYM4 ZNF160 ZNF410 ZNF417 ZNF564 ZNF587
Entrez ID		10527	3987
HPRD ID		09280	03978
Ensembl ID		ENSG00000205339	ENSG00000169756
Uniprot IDs		B3KNG9 O95373	A0A8Q3WKI3 A0A8Q3WKJ2 A0A8Q3WKK6 A0A8Q3WKP0 F8WC86 P48059
PDB IDs			1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q 4HI8 4HI9 6MIF 7D2S 7D2T 7D2U 7LT9
Enriched GO Terms of Interacting Partners?		Cytosolic Ribosome RNA Import Into Nucleus RNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Importin-alpha Family Protein Binding Negative Regulation Of Ubiquitin Protein Ligase Activity Ubiquitin Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleolus Cytoplasmic Translation Regulation Of Proteolysis MRNA 5'-UTR Binding Regulation Of Ubiquitin-protein Transferase Activity Ribonucleoprotein Complex Structural Constituent Of Ribosome Protein-containing Complex Nucleus Spindle Organization Negative Regulation Of Catalytic Activity Ribosome RRNA Binding Positive Regulation Of Binding Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Catalytic Activity Protein Stabilization Cytosolic Large Ribosomal Subunit Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Cell Development Response To Vitamin B2 C/EBP Complex Regulation Of Focal Adhesion Assembly Regulation Of Protein Modification Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Protein Ubiquitination Regulation Of Cell-substrate Junction Organization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Chromatin DNA Binding CHOP-C/EBP Complex	Cell-substrate Adhesion Substrate Adhesion-dependent Cell Spreading Cell-matrix Adhesion SMAD Binding Positive Regulation Of Cell Differentiation Metal Ion Binding Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Filament-based Process Integrin-mediated Signaling Pathway Zinc Ion Binding Positive Regulation Of Mesenchymal Stem Cell Proliferation Detection Of Muscle Stretch Telethonin Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Cell Differentiation Structural Constituent Of Muscle Positive Regulation Of Stem Cell Proliferation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Stress Fiber Assembly Regulation Of DNA-templated Transcription Integrin Activation Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Sarcomere Z Disc Positive Regulation Of Epithelial To Mesenchymal Transition Actinin Binding Positive Regulation Of Actin Filament Bundle Assembly Integrin Binding Cardiac Myofibril Assembly Regulation Of Actin Filament Organization Nucleus Anchoring Junction I-SMAD Binding Actin Cytoskeleton Positive Regulation Of Supramolecular Fiber Organization
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