IPO7 and NOSIP

Number of citations of the paper that reports this interaction (PubMedID 36690276)
66

Data Source:
BioGRID (pull down)

		IPO7	NOSIP
Description		importin 7	nitric oxide synthase interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding GTPase Regulator Activity Small GTPase Binding Histone Binding SMAD Binding	RNA Binding Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity Molecular Sequestering Activity
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Innate Immune Response Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Odontoblast Differentiation	Negative Regulation Of Catalytic Activity Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Negative Regulation Of Nitric-oxide Synthase Activity
Pathways			NOSIP mediated eNOS trafficking
Drugs
Diseases
GWAS		Interleukin-10 levels ( 22205395)	Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		14 interacting genes: AKTIP CEBPA H1-0 KPNB1 LIMS1 LINC01554 NOSIP PTEN RAN RNF10 RPL23A RPL5 RPS7 SRP19	13 interacting genes: CEBPA IPO13 IPO5 IPO7 KPNA1 KPNB1 NOS1 NOS3 PPP2CA UBC UBE2D3 XPO1 ZNF410
Entrez ID		10527	51070
HPRD ID		09280	17642
Ensembl ID		ENSG00000205339	ENSG00000142546
Uniprot IDs		B3KNG9 O95373	A0A075B6F9 Q9Y314
PDB IDs			8C6J 9FMD
Enriched GO Terms of Interacting Partners?		Cytosolic Ribosome RNA Import Into Nucleus RNA Binding Regulation Of Ubiquitin-dependent Protein Catabolic Process Importin-alpha Family Protein Binding Negative Regulation Of Ubiquitin Protein Ligase Activity Ubiquitin Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleolus Cytoplasmic Translation Regulation Of Proteolysis MRNA 5'-UTR Binding Regulation Of Ubiquitin-protein Transferase Activity Ribonucleoprotein Complex Structural Constituent Of Ribosome Protein-containing Complex Nucleus Spindle Organization Negative Regulation Of Catalytic Activity Ribosome RRNA Binding Positive Regulation Of Binding Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Catalytic Activity Protein Stabilization Cytosolic Large Ribosomal Subunit Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Cell Development Response To Vitamin B2 C/EBP Complex Regulation Of Focal Adhesion Assembly Regulation Of Protein Modification Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Protein Ubiquitination Regulation Of Cell-substrate Junction Organization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metabolic Process Chromatin DNA Binding CHOP-C/EBP Complex	Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Pore Intracellular Protein Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Establishment Of Localization In Cell Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Nucleus NLS-bearing Protein Import Into Nucleus Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Small GTPase Binding Ribosomal Protein Import Into Nucleus Cadmium Ion Binding Protein Transport L-arginine Catabolic Process Intracellular Transport Arginine Binding Nuclear Envelope Establishment Of Protein Localization NLS-dependent Protein Nuclear Import Complex Nuclear Membrane FMN Binding Cellular Localization Arginine Metabolic Process Regulation Of Cell Cycle Nitric Oxide Mediated Signal Transduction Nitric Oxide Biosynthetic Process Nucleoplasm Regulation Of The Force Of Heart Contraction Intracellular Protein Localization RNA Transport Nitric Oxide Metabolic Process Negative Regulation Of Potassium Ion Transport Reactive Nitrogen Species Metabolic Process NADP Binding Hsp90 Protein Binding Blood Circulation Cell Redox Homeostasis Regulation Of Protein Localization Response To Fluid Shear Stress Nucleobase-containing Compound Transport Regulation Of Hippo Signaling Mitotic Metaphase Chromosome Alignment Negative Regulation Of Blood Pressure
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