IPO7 and RPL5

Number of citations of the paper that reports this interaction (PMID 9687515)
135

Data Source:
HPRD (in vitro)

		IPO7	RPL5
Gene Name		importin 7	ribosomal protein L5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytoplasm Membrane	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	Small GTPase Regulator Activity Transporter Activity Protein Binding Ran GTPase Binding Histone Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Poly(A) RNA Binding
	Biological Process	Protein Import Into Nucleus Signal Transduction Viral Process Innate Immune Response Regulation Of Catalytic Activity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Viral Process Viral Life Cycle Viral Transcription Ribosomal Large Subunit Biogenesis Cellular Protein Metabolic Process
Pathways			Nonsense-Mediated Decay (NMD) Translation SRP-dependent cotranslational protein targeting to membrane Eukaryotic Translation Termination Peptide chain elongation Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression Influenza Life Cycle Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Influenza Viral RNA Transcription and Replication GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Initiation Formation of a pool of free 40S subunits Eukaryotic Translation Elongation Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Height ( 20881960) Multiple sclerosis ( 19525955 17660530)
Protein-Protein Interactions		7 interactors: H1F0 KPNB1 RAN RPL23A RPL5 RPS7 SRP19	21 interactors: CSNK2A1 CSNK2B DCC EIF5A HARS IPO13 IPO5 IPO7 KPNB1 MAP3K14 MDM2 NVL PDCD4 PPM1D SPP1 SURF2 TNIP1 TNPO1 TSC22D1 UPF2 VHL
Entrez ID		10527	6125
HPRD ID		09280	04699
Ensembl ID		ENSG00000205339	ENSG00000122406
Uniprot IDs		B3KNG9 O95373	A2RUM7 B3KTM6 P46777
PDB IDs			3J3B
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization To Organelle Protein Targeting Viral Life Cycle Protein Localization To Organelle Cytoplasmic Transport SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Intracellular Protein Transport Protein Localization To Endoplasmic Reticulum Aromatic Compound Catabolic Process Protein Targeting To Membrane Viral Process Cellular Protein Localization Protein Transport Establishment Of Protein Localization To Membrane Establishment Of Protein Localization Intracellular Transport Cellular Macromolecule Catabolic Process Viral Transcription Protein Localization To Membrane Protein Localization Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Establishment Of Localization In Cell Cellular Localization Translational Termination Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Apoptotic DNA Fragmentation Translational Elongation RNA Catabolic Process Cellular Protein Complex Disassembly Ribosome Biogenesis Translation Protein Complex Disassembly Intracellular Transport Of Virus Translational Initiation Apoptotic Nuclear Changes Catabolic Process Membrane Organization Ribonucleoprotein Complex Biogenesis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis DNA Catabolic Process, Endonucleolytic Nucleobase-containing Compound Metabolic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transport	Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Cytoplasmic Transport Protein Localization To Organelle Establishment Of Protein Localization To Organelle Negative Regulation Of Collateral Sprouting Ribosomal Protein Import Into Nucleus Protein Targeting NLS-bearing Protein Import Into Nucleus Intracellular Protein Transport Cellular Protein Localization Viral Process Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Proliferation Programmed Cell Death Intracellular Transport Cell Death Death Protein Import Into Nucleus, Translocation Cellular Localization Response To External Stimulus Protein Localization Protein Transport Establishment Of Localization In Cell Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Cellular Response To UV-C Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Vitamin B1 Negative Regulation Of Axonogenesis Chemotaxis MRNA Export From Nucleus Regulation Of MAPK Cascade Histidyl-tRNA Aminoacylation Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury RNA Export From Nucleus Regulation Of Catalytic Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Developmental Growth Spinal Cord Ventral Commissure Morphogenesis Netrin-activated Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Growth Mitotic Cell Cycle Cellular Response To Hypoxia
Tagcloud ?			biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Difference) ?			biogenesis biosynthesis dehydrogenase deoxy disrupts dually genotoxic gtp guanine imp impdh2 inauzhin inosine inz mdm2 monophosphate notion nucleostemin pools ribonucleotide ribosomal rpl11 rps rrna rs sirt1 stressor suppresses surprisingly
Tagcloud (Intersection) ?